Poursamar, S. A., Hatami, J., Lehner, A. N., da Silva, C. L., Ferreira, F. C. and Antunes, A. P. M. (2016) Potential application of gelatin scaffolds prepared through in situ gas foaming in skin tissue engineering. International Journal of Polymeric Materials and Polymeric Biomaterials. 65(6), pp. 315-322. 0091-4037.
| Item Type: | Article |
|---|---|
| Abstract: | Gelatin’s excellent foaming ability allows the application of in situ gas foaming as a preparation technique for porous scaffold development. Here, a new iterative experimental design for in situ gas foaming method is reported. The prepared scaffolds were studied for applying the findings to the future skin tissue engineering scaffolds. The thermal stability, mechanical properties, and pore structure of the scaffolds are reported and their degradation resistance by using collagenase enzyme and their cytotoxicity by using fibroblasts were studied. The results of this study demonstrated that gas foaming method can be modified to produce an interconnected porous structure with enhanced mechanical properties. |
| Uncontrolled Keywords: | Gelatin, wound dressing, gas foaming, tensile strength, cytotoxicity |
| Subjects: |
R Medicine > R Medicine (General) > R856 Biomedical engineering. Electronics. Instrumentation. > R857.T55 Tissue engineering T Technology > TP Chemical technology > TP248.13 Biotechnology |
| Creators: | Poursamar, Seyed Ali, Hatami, Javad, Lehner, Alexander N, da Silva, Claudia L, Ferreira, Frederico Castelo and Antunes, A Paula M |
| Publisher: | Taylor and Francis |
| Faculties, Divisions and Institutes: |
University Faculties, Divisions and Research Centres - OLD > Research Group > Institute for Creative Leather Technologies University Faculties, Divisions and Research Centres - OLD > Research Centre > Institute of Health and Wellbeing > Centre for Physical Activity and Chronic Disease University Faculties, Divisions and Research Centres - OLD > Research Centre > Institute of Health and Wellbeing > Ageing Research Centre Research Institutes > Institute for Creative Leather Technologies Research Centres > Centre for Health Sciences and Services Research Centres > Centre for Physical Activity and Life Sciences |
| Date: | 8 January 2016 |
| Date Type: | Publication |
| Page Range: | pp. 315-322 |
| Journal or Publication Title: | International Journal of Polymeric Materials and Polymeric Biomaterials |
| Volume: | 65 |
| Number: | 6 |
| Language: | English |
| DOI: | https://doi.org/10.1080/00914037.2015.1119688 |
| ISSN: | 0091-4037 |
| Status: | Published / Disseminated |
| Refereed: | Yes |
| URI: | http://nectar.northampton.ac.uk/id/eprint/8218 |
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