Hargreaves, C. E., Rose-Zerilli, M. J. J., Machado, L., Iriyama, C., Hollox, E. J., Cragg, M. S. and Strefford, J. C. (2015) Fcγ receptors: genetic variation, function, and disease. Immunological Reviews. 268(1), pp. 6-24. 1600-065X.
| Item Type: | Article |
|---|---|
| Abstract: | Fcγ receptors (FcγRs) are key immune receptors responsible for the effective control of both humoral and innate immunity and are central to maintaining the balance between generating appropriate responses to infection and preventing autoimmunity. When this balance is lost, pathology results in increased susceptibility to cancer, autoimmunity, and infection. In contrast, optimal FcγR engagement facilitates effective disease resolution and response to monoclonal antibody immunotherapy. The underlying genetics of the FcγR gene family are a central component of this careful balance. Complex in humans and generated through ancestral duplication events, here we review the evolution of the gene family in mammals, the potential importance of copy number, and functionally relevant single nucleotide polymorphisms, as well as discussing current approaches and limitations when exploring genetic variation in this region. |
| Uncontrolled Keywords: | Fc receptors, genetics, immunotherapy, antibodies |
| Subjects: |
Q Science > QR Microbiology > QR180 Immunology R Medicine > RM Therapeutics. Pharmacology > RM270 Immunotherapy. Serotherapy Q Science > QH Natural history > QH426 Genetics > QH438.7 Human genetics |
| Creators: | Hargreaves, Chantal E, Rose-Zerilli, Matthew J J, Machado, Lee, Iriyama, Chisako, Hollox, Edward J, Cragg, Mark S and Strefford, Jonathan C |
| Publisher: | John Wiley |
| Faculties, Divisions and Institutes: |
University Faculties, Divisions and Research Centres - OLD > Faculty of Health & Society > Sports, Exercise & Life Sciences Faculties > Faculty of Health & Society > Sports, Exercise & Life Sciences |
| Date: | 26 October 2015 |
| Date Type: | Publication |
| Page Range: | pp. 6-24 |
| Journal or Publication Title: | Immunological Reviews |
| Volume: | 268 |
| Number: | 1 |
| Language: | English |
| DOI: | https://doi.org/10.1111/imr.12341 |
| ISSN: | 1600-065X |
| Status: | Published / Disseminated |
| URI: | http://nectar.northampton.ac.uk/id/eprint/7910 |
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