Northampton Electronic Collection of Theses and Research

Gelatin porous scaffolds fabricated using a modified gas foaming technique: Characterisation and cytotoxicity assessment

Poursamar, S. A., Hatami, J., Lehner, A. N., da Silva, C., Ferreira, F. and Antunes, A. P. M. (2015) Gelatin porous scaffolds fabricated using a modified gas foaming technique: Characterisation and cytotoxicity assessment. Materials Science and Engineering: C. 48 0928-4931.

Item Type: Article
Abstract: The current study presents an effective and simple strategy to obtain stable porous scaffolds from gelatin via a gas foaming method. The technique exploits the intrinsic foaming ability of gelatin in the presence of CO2 to obtain a porous structure stabilised with glutaraldehyde. The produced scaffolds were characterised using physical and mechanical characterisation methods. The results showed that gas foaming may allow the tailoring of the 3-dimensional structure of the scaffolds with an interconnected porous structure. To assess the effectiveness of the preparation method in mitigating the potential cytotoxicity risk of using glutaraldehyde as a crosslinker, direct and in-direct cytotoxicity assays were performed at different concentrations of glutaraldehyde. The results indicate the potential of the gas foaming method, in the preparation of viable tissue engineering scaffolds.
Uncontrolled Keywords: crosslinking, denaturation temperature, gas foaming, gelatin, tensile strength
Creators: Poursamar, Seyed Ali, Hatami, Javad, Lehner, Alexander N, da Silva, Claudio, Ferreira, Frederico and Antunes, A Paula M
Faculties, Divisions and Institutes: Research Institutes > Institute for Creative Leather Technologies
Research Centres > Centre for Health Sciences and Services
Research Centres > Centre for Physical Activity and Life Sciences
Date: 1 March 2015
Date Type: Publication
Journal or Publication Title: Materials Science and Engineering: C
Volume: 48
Language: English
DOI: https://doi.org/10.1016/j.msec.2014.10.074
ISSN: 0928-4931
Status: Published / Disseminated
Refereed: Yes
URI: http://nectar.northampton.ac.uk/id/eprint/7178

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