Hardwick, R. J., Amogne, W., Mugusi, S., Yimer, G., Ngaimisi, E., Habtewold, A., Minzi, O., Makonnen, E., Janabi, M., Machado, L., Mugusi, F., Aderaye, G., Lindquist, L., Hollox, E. J. and Aklillu, E. (2011) β-Defensin genomic copy number is associated with HIV viral load and immune reconstitution in sub-Saharan Africans. Poster presented to: Annual Congress of the British Society for Immunology, Liverpool, UK, 05-08 December 2011. (Unpublished)
| Item Type: | Conference or Workshop Item (Poster) |
|---|---|
| Abstract: | AIDS, caused by the retrovirus HIV, is the leading cause of death of economically-active people (age 15 59) in sub-Saharan Africa. It is characterised by high HIV viral load and reduced (<200 cells/mm3) CD4 + T-cell count. b-defensins are broad-spectrum antimicrobial genes that are also chemotactic for dendritic cells and T-cells through the CCR6. b-defensin genes have previously been shown to be copy number variable, that is, different individuals have different numbers of the same gene. In this cohort study we analysed the relationship between b-defensin genomic copy number and HIV viral load immediately prior to initiation of retroviral treatment in 627 Ethiopian and 325 Tanzanian HIV patients, some co-infected with tuberculosis. We also measured the response to Highly Active Antiretroviral Therapy (HAART) by measuring follow-up CD4+ T-cell counts and viral load counts in a subsection of these patients. We found that high b-defensin copy number was associated with increased baseline HIV viral load, independent of co-infection with tuberculosis and population of origin. We also found that high b-defensin copy number was associated with impaired immune reconstitution after initiation of HAART, as measured by CD4 count up to 48 weeks follow-up and virological failure (persistence of viremia with viral load >200 copies/ml). Given the known chemotactic role of b-de-fensins, our data suggest a model where b-defensins recruit HIV- permissive Th17 lymphocytes to mucosal sites via the chemokine receptor CCR6. E. Hollox and E. Aklillu are joint senior authors |
| Additional Information: | Abstracts also published in Immunology, Vol. 135, Suppl. 1, December 2011 |
| Subjects: |
R Medicine > RC Internal medicine > RC581 Immunologic diseases. Allergy > RC606.63 HIV infections Q Science > QR Microbiology > QR180 Immunology |
| Creators: | Hardwick, Robert J, Amogne, Wondwossen, Mugusi, Sabina, Yimer, Getnet, Ngaimisi, Eliford, Habtewold, Abiy, Minzi, Omary, Makonnen, Eyasu, Janabi, Mohammed, Machado, Lee, Mugusi, Ferdinand, Aderaye, Getachew, Lindquist, Lars, Hollox, Edward J and Aklillu, Eleni |
| Northamptonshire and East Midlands: | Health |
| Faculties, Divisions and Institutes: |
University Faculties, Divisions and Research Centres - OLD > Faculty of Health & Society > Sports, Exercise & Life Sciences University Faculties, Divisions and Research Centres - OLD > Research Centre > Institute of Health and Wellbeing > Ageing Research Centre Faculties > Faculty of Health & Society > Sports, Exercise & Life Sciences Research Centres > Centre for Health Sciences and Services Research Centres > Centre for Physical Activity and Life Sciences |
| Date: | December 2011 |
| Date Type: | Presentation |
| Event Title: | Annual Congress of the British Society for Immunology |
| Event Dates: | 05-08 December 2011 |
| Event Location: | Liverpool, UK |
| Event Type: | Conference |
| Language: | English |
| Status: | Unpublished |
| URI: | http://nectar.northampton.ac.uk/id/eprint/6851 |
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