Prince, K., Campbell, J., Picton, P. and Turner, S. J. (2005) A computational model simulating how pain modulation can occur through transcutaneous electrical nerve stimulation (TENS). In: Petratos, P. and Michalopoulos, D. (eds.) Computer Science and Information Systems: Selected Papers from the 1st International Conference on Computer Science and Information Systems on June 16-18, 2005. Athens, Greece: Athens Institute for Education and Research (ATINER). 9608867231. pp. 15-32.
| Item Type: | Conference Proceedings |
|---|---|
| Abstract: | In 1965 Melzack and Wall proposed the influential gate control theory of pain. This theory postulates that the substantia gelatinosa, located within the spinal cord, acts like a gating mechanism, which modulates the flow of information through the spinal cord to the brain and thus impacts on the pain experience. Subsequent research has, in general, supported this theory. The explicitness of the theory and its well-defined architecture was translated into a mathematical model by Britton and Skevington in 1996. However, the use of such modelling has been very limited in the field of pain. he fact that pain is still relatively a poorly understood phenomenon despite the abundance of literature that is available and because of the difficulty in obtaining some experimental data, suggest that it is an ideal candidate for mathematical modelling. This paper successfully replicates the mathematical model as presented by Britton and Skevington. It uses this as a platform to develop the model further to test some of the assumptions made in its original development and, more importantly, to produce a more biologically plausible model that can be used for further applications. |
| Subjects: |
R Medicine > RB Pathology > RB127 Manifestations of disease > RB127.H355 Pain. Measurement R Medicine > RM Therapeutics. Pharmacology > RM871 Electrotherapeutics |
| Creators: | Prince, Karen, Campbell, Jackie, Picton, Philip and Turner, Scott J |
| Editors: | Petratos, Panagiotis and Michalopoulos, Demetrios |
| Publisher: | Athens Institute for Education and Research (ATINER) |
| Northamptonshire and East Midlands: | Health |
| Faculties, Divisions and Institutes: |
University Faculties, Divisions and Research Centres - OLD > School of Applied Sciences (to 2009) University Faculties, Divisions and Research Centres - OLD > Faculty of Health & Society |
| Date: | 2005 |
| Date Type: | Publication |
| Page Range: | pp. 15-32 |
| Title of Book: | Computer Science and Information Systems: Selected Papers from the 1st International Conference on Computer Science and Information Systems on June 16-18, 2005 |
| Event Title: | International Conference on Computer Science and Information Systems |
| Event Dates: | 16-18 June 2005 |
| Place of Publication: | Athens, Greece |
| Event Location: | Athens, Greece |
| Event Type: | Conference |
| Number of Pages: | 440 |
| Language: | English |
| ISBN: | 9608867231 |
| Status: | Published / Disseminated |
| URI: | http://nectar.northampton.ac.uk/id/eprint/6006 |
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