Machado, L., Jarrett, R., Morgan, S., Murray, P., Hunter, B., Hamilton, E., Crocker, J., Thomas, W., Steven, N., Ismail, T., Chapman, A., Adams, D. H. and Lee, S. P. (2009) Expression and function of T cell homing molecules in Hodkins's lymphoma. Cancer Immunology, Immunotherapy. 58(1), pp. 85-94. 0340-7004.
| Item Type: | Article |
|---|---|
| Abstract: | Circulating T lymphocytes enter a tissue if they express appropriate chemokine receptors and adhesion molecules to engage ligands presented at this site. To aid rational development of T cell-based therapies for Hodgkin’s lymphoma (HL), we have assessed the expression and function of homing receptors on tumour-inWltrating T cells in HL and compared them with T cells from unaVected lymph nodes and colorectal cancer tissue. Chemokine receptors CXCR3, CXCR4 and CCR7 were expressed on a large proportion of T cells within HL tissue and mediated chemotaxis to puriWed chemokine. The corresponding ligands (CXCL10, CXCL12, CCL21) were expressed on the malignant cells and/or vascular endothelium. Adhesion molecules including CD62L were widely expressed on HL-derived T cells and their corresponding ligands were detected on vessels within the tumour. This homing phenotype was distinct from T cells isolated from colorectal cancer, but matched closely the phenotype of T cells from unaVected lymph nodes. Thus, T cell recruitment to HL resembles entry of naïve/central memory T cells into normal lymph nodes. This has important implications for current approaches to treat HL using T cells activated and expanded in vitro that lack CCR7 and CD62L expression |
| Uncontrolled Keywords: | Chemokines, Hodgkin’s lymphoma, tumour immunity, T cell homing |
| Subjects: |
R Medicine > RC Internal medicine > RC254 Neoplasms. Tumors. Oncology Q Science > QR Microbiology > QR180 Immunology |
| Creators: | Machado, Lee, Jarrett, Ruth, Morgan, Susan, Murray, Paul, Hunter, Beatrix, Hamilton, Emma, Crocker, John, Thomas, Wendy, Steven, Neil, Ismail, Tariq, Chapman, Ann, Adams, David H and Lee, S P |
| Publisher: | Springer |
| Faculties, Divisions and Institutes: |
University Faculties, Divisions and Research Centres - OLD > Faculty of Health & Society > Sports, Exercise & Life Sciences University Faculties, Divisions and Research Centres - OLD > Research Centre > Institute of Health and Wellbeing > Ageing Research Centre Faculties > Faculty of Health & Society > Sports, Exercise & Life Sciences Research Centres > Centre for Health Sciences and Services Research Centres > Centre for Physical Activity and Life Sciences |
| Date: | January 2009 |
| Date Type: | Publication |
| Page Range: | pp. 85-94 |
| Journal or Publication Title: | Cancer Immunology, Immunotherapy |
| Volume: | 58 |
| Number: | 1 |
| Language: | English |
| DOI: | https://doi.org/10.1007/s00262-008-0528-z |
| ISSN: | 0340-7004 |
| Status: | Published / Disseminated |
| Related URLs: | |
| URI: | http://nectar.northampton.ac.uk/id/eprint/5705 |
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