Engeham, S., Mdaki, K., Jewell, K., Austin, R., Lehner, A. N. and Langley-Evans, S. C. (2012) Mitochondrial respiration is decreased in rat kidney following fetal exposure to a maternal low-protein diet. Journal of Nutrition and Metabolism. 2012, pp. 1-10. 2090-0724.
| Item Type: | Article |
|---|---|
| Abstract: | Maternal protein restriction in rat pregnancy is associated with impaired renal development and age-related loss of renal function in the resulting offspring. Pregnant rats were fed either control or low-protein (LP) diets, and kidneys from their male offspring were collected at 4, 13, or 16 weeks of age. Mitochondrial state 3 and state 4 respiratory rates were decreased by a third in the LP exposed adults. The reduction in mitochondrial function was not explained by complex IV deficiency or altered expression of the complex I subunits that are typically associated with mitochondrial dysfunction. Similarly, there was no evidence that LP-exposure resulted in greater oxidative damage to the kidney, differential expression of ATP synthetase β-subunit, and ATP-ADP translocase 1. mRNA expression of uncoupling protein 2 was increased in adult rats exposed to LP in utero, but there was no evidence of differential expression at the protein level. Exposure to maternal undernutrition is associated with a decrease in mitochondrial respiration in kidneys of adult rats. In the absence of gross disturbances in respiratory chain protein expression, programming of coupling efficiency may explain the long-term impact of the maternal diet. |
| Subjects: |
R Medicine > RC Internal medicine > RC620 Nutritional diseases. Deficiency diseases Q Science > QP Physiology > QP501 Animal biochemistry |
| Creators: | Engeham, S, Mdaki, Kennedy, Jewell, K, Austin, R, Lehner, Alexander N and Langley-Evans, Simon C |
| Publisher: | Hindawi |
| Faculties, Divisions and Institutes: |
University Faculties, Divisions and Research Centres - OLD > Faculty of Health & Society > Sports, Exercise & Life Sciences University Faculties, Divisions and Research Centres - OLD > Research Centre > Institute of Health and Wellbeing > Ageing Research Centre University Faculties, Divisions and Research Centres - OLD > Research Centre > Institute of Health and Wellbeing > Centre for Physical Activity and Chronic Disease Faculties > Faculty of Health & Society > Sports, Exercise & Life Sciences Research Centres > Centre for Health Sciences and Services Research Centres > Centre for Physical Activity and Life Sciences |
| Date: | 27 March 2012 |
| Date Type: | Publication |
| Page Range: | pp. 1-10 |
| Journal or Publication Title: | Journal of Nutrition and Metabolism |
| Volume: | 2012 |
| Language: | English |
| DOI: | https://doi.org/10.1155/2012/989037 |
| ISSN: | 2090-0724 |
| Status: | Published / Disseminated |
| Refereed: | Yes |
| URI: | http://nectar.northampton.ac.uk/id/eprint/5259 |
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