Posthumus, M., Raleigh, S. M., Ribbans, W. J., Schwellnus, M. P. and Collins, M. (2010) A functional variant within the MMP3 gene does not associate with human range of motion. Journal of Science and Medicine in Sport. 13(6), pp. 630-632. 1440-2440.
| Item Type: | Article |
|---|---|
| Abstract: | A recent heritability study has demonstrated that human range of motion (ROM) has a substantial genetic component. Furthermore, the COL5A1BstUI RFLP has now been identified as the first gene variant to be associated with human ROM. Interestingly, this variant is known to interact with a functional variant within the MMP3 gene (rs679620) to increase risk of Achilles tendinopathy. We sought to determine whether the MMP3 rs679620 variant was associated with ROM both as a single marker and as an interacting marker with the COL5A1 BstUI RFLP. One hundred and twenty one participants were included in this study. All participants were genotyped for the MMP3 rs679620 variant, and performed passive straight leg raise (SLR) and sit and reach (SR) measurements. There were no significant differences in left leg SLR (L-SLR), right leg SLR (R-SLR), or SR measurements between the genotype groups (L-SLR, P=0.494; R-SLR, P=0.435; SR, P=0.266). Furthermore, there was no evidence of an interaction between the COL5A1 BstUI RFLP and the MMP3 rs679620 variant. Our study suggests that the MMP3 rs679620 variant does not associate with passive ROM. |
| Subjects: |
R Medicine > RC Internal medicine > RC1200 Sports Medicine Q Science > QP Physiology > QP301 Exercise and sports physiology R Medicine > RB Pathology > RB151 Theories of disease. Etiology. Pathogenesis > RB155 Medical genetics |
| Creators: | Posthumus, Michael, Raleigh, Stuart M, Ribbans, William J, Schwellnus, M P and Collins, M |
| Publisher: | Sports Medicine Australia |
| Faculties, Divisions and Institutes: |
University Faculties, Divisions and Research Centres - OLD > Faculty of Health & Society > Sports, Exercise & Life Sciences University Faculties, Divisions and Research Centres - OLD > Research Centre > Institute of Health and Wellbeing > Centre for Physical Activity and Chronic Disease Faculties > Faculty of Health & Society > Sports, Exercise & Life Sciences Research Centres > Centre for Health Sciences and Services Research Centres > Centre for Physical Activity and Life Sciences |
| Date: | November 2010 |
| Date Type: | Publication |
| Page Range: | pp. 630-632 |
| Journal or Publication Title: | Journal of Science and Medicine in Sport |
| Volume: | 13 |
| Number: | 6 |
| Language: | English |
| ISSN: | 1440-2440 |
| Status: | Published / Disseminated |
| Refereed: | Yes |
| URI: | http://nectar.northampton.ac.uk/id/eprint/3323 |
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