Zeugolis, D. I., Paul, R. G. and Attenburrow, G. E. (2008) Post-self-assembly experimentation on extruded collagen fibres for tissue engineering applications. Acta Biomaterialia. 4(6), pp. 1646-1656. 1742-7061.
| Item Type: | Article |
|---|---|
| Abstract: | Extruded collagen fibres have been shown to constitute a biomimetic three-dimensional scaffold with numerous tissue engineering applications. The multi-step fabrication process of this material provides opportunities for further advancements to improve the properties of the final product. Herein we investigated the influence of the post-self-assembly washing baths on the structural, mechanical and thermal properties of these fibres. The surface morphology and the inter-fibre packing were similar for every treatment. The overnight incubation in isopropanol yielded fibres with the highest temperature and energy of denaturation (p < 0.013). Typical s- and j-shape stress–strain curves were obtained for all treatments in the dry and wet state respectively. Rehydration of the fibres resulted in increased fibre diameter (p < 0.006) and reduced stress (p < 0.001), force (p < 0.001) and modulus (p < 0.002) values for every treatment. In the dry state, the alcohol-treated fibres were characterized by the highest stress (p < 0.002) values; whilst in the wet state the Tris–HCl-treated fibres were the weakest (p < 0.006). For every treatment, in both dry and wet state, a strong and inverse relationship between the fibre diameter and the stress at break was observed. Overall, the fibres produced were characterized by properties similar to those of native tissues. |
| Uncontrolled Keywords: | Extruded collagen fibres; post-self-assembly; mechanical properties; thermal properties; structural characteristics |
| Subjects: |
R Medicine > R Medicine (General) > R856 Biomedical engineering. Electronics. Instrumentation. > R857.T55 Tissue engineering T Technology > TP Chemical technology > TP248.13 Biotechnology Q Science > QP Physiology > QP501 Animal biochemistry > QP552.C6 Collagen |
| Creators: | Zeugolis, D I, Paul, R G and Attenburrow, Geoff E |
| Publisher: | Elsevier |
| Faculties, Divisions and Institutes: |
University Faculties, Divisions and Research Centres - OLD > Research Centre > Centre for Research on Leather and Materials Science Research Institutes > Institute for Creative Leather Technologies |
| Date: | November 2008 |
| Date Type: | Publication |
| Page Range: | pp. 1646-1656 |
| Journal or Publication Title: | Acta Biomaterialia |
| Volume: | 4 |
| Number: | 6 |
| Language: | English |
| DOI: | https://doi.org/10.1016/j.actbio.2008.05.015 |
| ISSN: | 1742-7061 |
| Status: | Published / Disseminated |
| Refereed: | Yes |
| URI: | http://nectar.northampton.ac.uk/id/eprint/1873 |
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