Marschalek, J., Egarter, C., Vytiska-Binsdorfer, E., Obruca, A., Campbell, J., Harris, P., van Santen, M., Lesoine, B., Ott, J. and Franz, M. (2020) Pregnancy rates after slow-release insemination (SRI) and standard bolus intrauterine insemination (IUI) – A multicentre randomised, controlled trial. Scientific Reports. 10(1) 2045-2322.
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| Item Type: | Article |
|---|---|
| Abstract: | Abstract: This multicentre, randomised, controlled cross-over trial was designed to investigate the effect of intra-uterine slow-release insemination (SRI) on pregnancy rates in women with confirmed infertility or the need for semen donation who were eligible for standard bolus intra-uterine insemination (IUI). Data for a total of 182 women were analysed after randomisation to receive IUI (n = 96) or SRI (n = 86) first. The primary outcome was serological pregnancy defined by a positive beta human chorionic gonadotropin test, two weeks after insemination. Patients who did not conceive after the first cycle switched to the alternative technique for the second cycle: 44 women switched to IUI and 58 switched to SRI. In total, there were 284 treatment cycles (IUI: n = 140; SRI: n = 144). Pregnancy rates following SRI and IUI were 13.2% and 10.0%, respectively, which was not statistically significant (p = 0.202). A statistically significant difference in pregnancy rates for SRI versus IUI was detected in women aged under 35 years. In this subgroup, the pregnancy rate with SRI was 17% compared to 7% with IUI (relative risk 2.33; p = 0.032) across both cycles. These results support the hypothesis that the pregnancy rate might be improved with SRI compared to standard bolus IUI, especially in women aged under 35 years. |
| Creators: | Marschalek, Julian, Egarter, Christian, Vytiska-Binsdorfer, Elisabeth, Obruca, Andreas, Campbell, Jackie, Harris, Philip, van Santen, Maarten, Lesoine, Bernd, Ott, Johannes and Franz, Maximilian |
| Faculties, Divisions and Institutes: | ?? HSRES ?? |
| Date: | 7 May 2020 |
| Date Type: | Publication |
| Journal or Publication Title: | Scientific Reports |
| Volume: | 10 |
| Number: | 1 |
| Number of Pages: | 9 |
| Language: | English |
| DOI: | https://doi.org/10.1038/s41598-020-64164-4 |
| ISSN: | 2045-2322 |
| Status: | Published / Disseminated |
| Refereed: | Yes |
| Related URLs: | |
| URI: | http://nectar.northampton.ac.uk/id/eprint/12869 |
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