Poursamar, S. A., Hatami, J., Lehner, A. N., da Silva, C., Ferreira, F. and Antunes, A. P. M. (2015) Gelatin porous scaffolds fabricated using a modified gas foaming technique: Characterisation and cytotoxicity assessment. Materials Science and Engineering: C. 48, pp. 63-70. 0928-4931.
Accepted version (462kB) |
| Item Type: | Article |
|---|---|
| Abstract: | The current study presents an effective and simple strategy to obtain stable porous scaffolds from gelatin via a gas foaming method. The technique exploits the intrinsic foaming ability of gelatin in the presence of CO2 to obtain a porous structure stabilised with glutaraldehyde. The produced scaffolds were characterised using physical and mechanical characterisation methods. The results showed that gas foaming may allow the tailoring of the 3-dimensional structure of the scaffolds with an interconnected porous structure. To assess the effectiveness of the preparation method in mitigating the potential cytotoxicity risk of using glutaraldehyde as a crosslinker, direct and in-direct cytotoxicity assays were performed at different concentrations of glutaraldehyde. The results indicate the potential of the gas foaming method, in the preparation of viable tissue engineering scaffolds. |
| Uncontrolled Keywords: | gelatin, gas foaming, crosslinking, tensile strength, denaturation temperature |
| Subjects: |
R Medicine > R Medicine (General) > R856 Biomedical engineering. Electronics. Instrumentation. > R857.T55 Tissue engineering T Technology > TP Chemical technology > TP248.13 Biotechnology |
| Creators: | Poursamar, Seyed Ali, Hatami, Javad, Lehner, Alexander N, da Silva, Claudio, Ferreira, Frederico and Antunes, A Paula M |
| Publisher: | Elsevier |
| Faculties, Divisions and Institutes: |
University Faculties, Divisions and Research Centres - OLD > Research Group > Institute for Creative Leather Technologies University Faculties, Divisions and Research Centres - OLD > School of Science and Technology (2010-2016) University Faculties, Divisions and Research Centres - OLD > Research Centre > Institute of Health and Wellbeing > Centre for Physical Activity and Chronic Disease University Faculties, Divisions and Research Centres - OLD > Research Centre > Institute of Health and Wellbeing > Ageing Research Centre Research Institutes > Institute for Creative Leather Technologies Research Centres > Centre for Health Sciences and Services Research Centres > Centre for Physical Activity and Life Sciences |
| Date: | 1 March 2015 |
| Date Type: | Publication |
| Page Range: | pp. 63-70 |
| Journal or Publication Title: | Materials Science and Engineering: C |
| Volume: | 48 |
| Language: | English |
| DOI: | https://doi.org/10.1016/j.msec.2014.10.074 |
| ISSN: | 0928-4931 |
| Status: | Published / Disseminated |
| Refereed: | Yes |
| URI: | http://nectar.northampton.ac.uk/id/eprint/7178 |
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