Gelatin porous scaffolds fabricated using a modified gas foaming technique: Characterisation and cytotoxicity assessment

Poursamar, S. A., Hatami, J., Lehner, A. N., da Silva, C., Ferreira, F. and Antunes, A. P. M. (2015) Gelatin porous scaffolds fabricated using a modified gas foaming technique: Characterisation and cytotoxicity assessment. Materials Science and Engineering: C. 48 0928-4931.

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Item Type:	Article
Abstract:	The current study presents an effective and simple strategy to obtain stable porous scaffolds from gelatin via a gas foaming method. The technique exploits the intrinsic foaming ability of gelatin in the presence of CO2 to obtain a porous structure stabilised with glutaraldehyde. The produced scaffolds were characterised using physical and mechanical characterisation methods. The results showed that gas foaming may allow the tailoring of the 3-dimensional structure of the scaffolds with an interconnected porous structure. To assess the effectiveness of the preparation method in mitigating the potential cytotoxicity risk of using glutaraldehyde as a crosslinker, direct and in-direct cytotoxicity assays were performed at different concentrations of glutaraldehyde. The results indicate the potential of the gas foaming method, in the preparation of viable tissue engineering scaffolds.
Uncontrolled Keywords:	crosslinking, denaturation temperature, gas foaming, gelatin, tensile strength
Creators:	Poursamar, Seyed Ali, Hatami, Javad, Lehner, Alexander N, da Silva, Claudio, Ferreira, Frederico and Antunes, A Paula M
Faculties, Divisions and Institutes:	Research Institutes > Institute for Creative Leather Technologies Research Centres > Centre for Health Sciences and Services Research Centres > Centre for Physical Activity and Life Sciences
Date:	1 March 2015
Date Type:	Publication
Journal or Publication Title:	Materials Science and Engineering: C
Volume:	48
Language:	English
DOI:	https://doi.org/10.1016/j.msec.2014.10.074
ISSN:	0928-4931
Status:	Published / Disseminated
Refereed:	Yes
URI:	http://nectar.northampton.ac.uk/id/eprint/7178

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