Northampton Electronic Collection of Theses and Research

Link-lock: an explanation of the chemical stabilisation of collagen

Covington, A. D., Song, L., Suparno, O., Koon, H. E. C. and Collins, M. J. (2010) Link-lock: an explanation of the chemical stabilisation of collagen. World Leather. 23(5), pp. 35-43. 0894-3087.

Item Type: Article
Abstract: Chemical modifications of collagen, of the type known in the leather tanning industry, can raise the denaturation temperature, from 6000C in its natural state, up to 130°C. There are only a few chemical reactions known to be capable of achieving the highest values and these have long been assumed to be unrelated. In this paper it is shown that all the stabilising mechanisms are fundamentally the same, regardless of chemical type. Any single component of a stabilising reaction has the effect of linking part of the collagen structure into the surrounding matrix of water: the outcome is always to confer moderate hydrothermal stability, up to 85°C. The effect is merely to hinder the shrinking/denaturation transition, so no single component reaction can exceed this moderate result. However, in addition, a second reaction component can be applied in the process, which may have the ability to lock the linked structure together, creating a macromolecular structure around the triple helices. The effect of the concerted interaction with collagen is to prevent more effectively the unravelling of the triple helices and thereby to raise the hydrothermal stability to much higher values of denaturation temperature. This proposed 'link-lock' mechanism opens up the possibility of achieving high collagen stability in new ways, which will contribute to the development of new collagenic biomaterials.
Uncontrolled Keywords: Link-lock, collagen
Subjects: T Technology > TS Manufactures > TS967 Chemistry and science of leather
T Technology > TS Manufactures > TS965 Leather technology > TS965.5 Tanning
Q Science > QP Physiology > QP501 Animal biochemistry > QP552.C6 Collagen
Creators: Covington, Anthony D, Song, Lijiang, Suparno, Ono, Koon, Hannah E C and Collins, Matthew J
Publisher: World Trades Publishing
Faculties, Divisions and Institutes: University Faculties, Divisions and Research Centres - OLD > School of Science and Technology (2010-2016)
Faculties > Faculty of Arts, Science & Technology > Engineering
Date: 30 September 2010
Date Type: Publication
Page Range: pp. 35-43
Journal or Publication Title: World Leather
Volume: 23
Number: 5
Language: English
ISSN: 0894-3087
Status: Published / Disseminated
Refereed: Yes
Related URLs:

Actions (login required)

Edit Item Edit Item