Northampton Electronic Collection of Theses and Research

Risk factors for suicide in individuals with depression: A systematic review

Hawton, K., Casañas i Comabella, C., Haw, C. and Saunders, K. (2013) Risk factors for suicide in individuals with depression: A systematic review. Journal of Affective Disorders. 147(1-3), pp. 17-28. 0165-0327.

Item Type: Article
Abstract: Depression is the most common psychiatric disorder in people who die by suicide. Awareness of risk factors for suicide in depression is important for clinicians. Methods In a systematic review of the international literature we identified cohort and case-control studies of people with depression in which suicide was an outcome, and conducted meta-analyses of potential risk factors. Results Nineteen studies (28 publications) were included. Factors significantly associated with suicide were: male gender (OR=1.76, 95% CI=1.08–2.86), family history of psychiatric disorder (OR=1.41, 95% CI=1.00–1.97), previous attempted suicide (OR=4.84, 95% CI=3.26–7.20), more severe depression (OR=2.20, 95% CI=1.05–4.60), hopelessness (OR=2.20, 95% CI=1.49–3.23) and comorbid disorders, including anxiety (OR=1.59, 95% CI=1.03–2.45) and misuse of alcohol and drugs (OR=2.17, 95% CI=1.77–2.66). Limitations There were fewer studies than suspected. Interdependence between risk factors could not be examined. Conclusions The factors identified should be included in clinical assessment of risk in depressed patients. Further large-scale studies are required to identify other relevant factors.
Uncontrolled Keywords: Depression, suicide, risk factors, systematic review
Subjects: R Medicine > RC Internal medicine > RC435 Psychiatry > RC530 Neuroses > RC537 Depression
R Medicine > RC Internal medicine > RC435 Psychiatry > RC554 Personality disorders. Behavior problems > RC569 Suicide
R Medicine > RC Internal medicine > RC435 Psychiatry
Creators: Hawton, Keith, Casañas i Comabella, Carolina, Haw, Camilla and Saunders, Kate
Publisher: Elsevier
Northamptonshire and East Midlands: Health
Faculties, Divisions and Institutes: University Faculties, Divisions and Research Centres - OLD > Faculty of Health & Society > Mental Health and Learning Disability
Faculties > Faculty of Health & Society > Nursing
Date: May 2013
Date Type: Publication
Page Range: pp. 17-28
Journal or Publication Title: Journal of Affective Disorders
Volume: 147
Number: 1-3
Language: English
ISSN: 0165-0327
Status: Published / Disseminated

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