Northampton Electronic Collection of Theses and Research

Expression and function of T cell homing molecules in Hodkins's lymphoma

Machado, L., Jarrett, R., Morgan, S., Murray, P., Hunter, B., Hamilton, E., Crocker, J., Thomas, W., Steven, N., Ismail, T., Chapman, A., Adams, D. H. and Lee, S. P. (2009) Expression and function of T cell homing molecules in Hodkins's lymphoma. Cancer Immunology, Immunotherapy. 58(1), pp. 85-94. 0340-7004.

Item Type: Article
Abstract: Circulating T lymphocytes enter a tissue if they express appropriate chemokine receptors and adhesion molecules to engage ligands presented at this site. To aid rational development of T cell-based therapies for Hodgkin’s lymphoma (HL), we have assessed the expression and function of homing receptors on tumour-inWltrating T cells in HL and compared them with T cells from unaVected lymph nodes and colorectal cancer tissue. Chemokine receptors CXCR3, CXCR4 and CCR7 were expressed on a large proportion of T cells within HL tissue and mediated chemotaxis to puriWed chemokine. The corresponding ligands (CXCL10, CXCL12, CCL21) were expressed on the malignant cells and/or vascular endothelium. Adhesion molecules including CD62L were widely expressed on HL-derived T cells and their corresponding ligands were detected on vessels within the tumour. This homing phenotype was distinct from T cells isolated from colorectal cancer, but matched closely the phenotype of T cells from unaVected lymph nodes. Thus, T cell recruitment to HL resembles entry of naïve/central memory T cells into normal lymph nodes. This has important implications for current approaches to treat HL using T cells activated and expanded in vitro that lack CCR7 and CD62L expression
Uncontrolled Keywords: Chemokines, Hodgkin’s lymphoma, tumour immunity, T cell homing
Subjects: R Medicine > RC Internal medicine > RC254 Neoplasms. Tumors. Oncology
Q Science > QR Microbiology > QR180 Immunology
Creators: Machado, Lee, Jarrett, Ruth, Morgan, Susan, Murray, Paul, Hunter, Beatrix, Hamilton, Emma, Crocker, John, Thomas, Wendy, Steven, Neil, Ismail, Tariq, Chapman, Ann, Adams, David H and Lee, S P
Publisher: Springer
Faculties, Divisions and Institutes: University Faculties, Divisions and Research Centres - OLD > Faculty of Health & Society > Sports, Exercise & Life Sciences
University Faculties, Divisions and Research Centres - OLD > Research Centre > Institute of Health and Wellbeing > Ageing Research Centre
Faculties > Faculty of Health & Society > Sports, Exercise & Life Sciences
Research Centres > Centre for Health Sciences and Services
Research Centres > Centre for Physical Activity and Life Sciences
Date: January 2009
Date Type: Publication
Page Range: pp. 85-94
Journal or Publication Title: Cancer Immunology, Immunotherapy
Volume: 58
Number: 1
Language: English
ISSN: 0340-7004
Status: Published / Disseminated
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