Northampton Electronic Collection of Theses and Research

A case series of clozapine for borderline personality disorder

Frogley, C., Anagnostakis, K., Mitchell, S., Mason, F., Taylor, D., Dickens, G. and Picchioni, M. (2013) A case series of clozapine for borderline personality disorder. Annals of Clinical Psychiatry. 25(2), pp. 125-134. 1040-1237.

Item Type: Article
Abstract: BACKGROUND: Borderline personality disorder (BPD) is a common, debilitating disorder for which the evidence base for treatment is modest. This case series aimed to explore preliminary evidence of clozapine's effectiveness for patients with severe BPD. METHODS: We examined the case notes of 22 female inpatients with a primary diagnosis of BPD who had started treatment with clozapine. Baseline routine clinical data were extracted from the records and at 6 monthly intervals thereafter, up to a maximum of 18 months after starting treatment. Patients also were interviewed about their experiences. RESULTS: We found evidence for a beneficial effect of clozapine across several clinical domains. Symptom severity, need for enhanced observations, use of additional medication, and the number of aggressive incidents all significantly improved after clozapine. The greatest improvements appeared within the first 6 months of initiating treatment. There also was a significant increase in weight. CONCLUSIONS: The results suggest that clozapine, with suitable health monitoring, may be beneficial for this clinical population. Larger, randomized, blinded, and controlled prospective studies are needed to confirm these findings
Subjects: R Medicine > RC Internal medicine > RC435 Psychiatry > RC554 Personality disorders. Behavior problems
R Medicine > RM Therapeutics. Pharmacology > RM300 Drugs and their actions
Creators: Frogley, C, Anagnostakis, K, Mitchell, S, Mason, F, Taylor, D, Dickens, Geoff and Picchioni, Marco
Publisher: American Academy of Clinical Psychiatrists
Faculties, Divisions and Institutes: University Faculties, Divisions and Research Centres - OLD > Faculty of Health & Society > Mental Health and Learning Disability
Faculties > Faculty of Health & Society > Nursing
Date: May 2013
Date Type: Publication
Page Range: pp. 125-134
Journal or Publication Title: Annals of Clinical Psychiatry
Volume: 25
Number: 2
Language: English
ISSN: 1040-1237
Status: Published / Disseminated
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