Brookes, C., Ribbans, B., El Khoury, L. and Raleigh, S. M. (2020) Variability within the human iNOS gene and Achilles tendon injuries: Evidence for a heterozygous advantage effect. Journal of Science and Medicine in Sport. 23(4), pp. 342-346. 1440-2440.
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| Item Type: | Article |
|---|---|
| Abstract: | Objectives: The aim of this case control genetic association study was to explore whether two variants within the inducible nitric oxide synthase (iNOS) gene, rs2779249 (C/A) and rs2248814 (A/G), influenced the risk of Achilles tendinopathy in a British population. Design: Candidate gene, case control association study. Method: We recruited 145 individuals diagnosed with Achilles tendon pathology and 132 asymptomatic controls. All participants were genotyped for the iNOS variants using qPCR and significant associations were discovered using a combination of Chi squared and ANOVA type analysis. Results: The CA genotype of the iNOS rs2779249 variant was protective and conformed to a heterozygous advantage model of inheritance as it was overrepresented in the control participants (p=0.009). In sex specific analysis the protective association persisted in male participants (p=0.016) but not in females. Unlike the rs2779249 variant, the rs2248814 variant was not associated with Achilles tendinopathy or Achilles tendon rupture. Conclusion: The rs2779249 CA genotype within the human iNOS gene appears to protect individuals from Achilles tendinopathy. This study further supports a genetic contribution to modifying the risk of Achilles tendon problems. The study also infers an important role for nitric oxide in tendon healing and/or degradation. |
| Creators: | Brookes, Charlotte, Ribbans, Bill, El Khoury, Louis and Raleigh, Stuart M |
| Faculties, Divisions and Institutes: | ?? ASSCI ?? |
| Date: | 1 April 2020 |
| Date Type: | Publication |
| Page Range: | pp. 342-346 |
| Journal or Publication Title: | Journal of Science and Medicine in Sport |
| Volume: | 23 |
| Number: | 4 |
| Number of Pages: | 5 |
| Language: | English |
| DOI: | https://doi.org/10.1016/j.jsams.2019.11.001 |
| ISSN: | 1440-2440 |
| Status: | Published / Disseminated |
| Refereed: | Yes |
| Related URLs: | |
| URI: | http://nectar.northampton.ac.uk/id/eprint/13347 |
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