Northampton Electronic Collection of Theses and Research

Tau mRNA is present in axonal RNA granules and is associated with elongation factor 1A

Malmqvist, T., Anthony, K. and Gallo, J.-M. (2014) Tau mRNA is present in axonal RNA granules and is associated with elongation factor 1A. Brain Research. 1584, pp. 22-27. 0006-8993.

Item Type: Article
Abstract: The microtubule-associated protein tau is predominantly localized in the axonal compartment over the entire length of the axon in neurons. The mechanisms responsible for the localization of tau in axons at long distance from the cell body are not properly understood. Using fluorescence in situ hybridization, we show that tau mRNA is present in the central and distal parts of the axons of cultured rat cortical neurons. Axonal tau mRNA is associated with granules which are distributed throughout the entire length of the axon, including the growth cone. We also show that tau mRNA-containing axonal particles are associated with elongation factor 1A, a component of the protein translation machinery. The presence of tau mRNA in axons might be at least part of the process by which tau is localized to distal axons.
Additional Information: This article is part of a Special Issue entitled RNA Metabolism 2013
Uncontrolled Keywords: Tau, mRNA, Axon, eEF1A
Subjects: Q Science > QP Physiology > QP501 Animal biochemistry > QP623.5 RNA
Creators: Malmqvist, Tony, Anthony, Karen and Gallo, Jean-Marc
Publisher: Elsevier
Faculties, Divisions and Institutes: University Faculties, Divisions and Research Centres - OLD > Research Centre > Institute of Health and Wellbeing > Ageing Research Centre
University Faculties, Divisions and Research Centres - OLD > Faculty of Health & Society > Sports, Exercise & Life Sciences
Faculties > Faculty of Health & Society > Sports, Exercise & Life Sciences
Research Centres > Centre for Health Sciences and Services
Research Centres > Centre for Physical Activity and Life Sciences
Date: 10 October 2014
Date Type: Publication
Page Range: pp. 22-27
Journal or Publication Title: Brain Research
Volume: 1584
Language: English
ISSN: 0006-8993
Status: Published / Disseminated
URI: http://nectar.northampton.ac.uk/id/eprint/8015

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