Northampton Electronic Collection of Theses and Research

Tau mRNA is present in axonal RNA granules and is associated with elongation factor 1A

Malmqvist, T., Anthony, K. and Gallo, J.-M. (2014) Tau mRNA is present in axonal RNA granules and is associated with elongation factor 1A. Brain Research. 1584, pp. 22-27. 0006-8993.

Item Type: Article
Abstract: The microtubule-associated protein tau is predominantly localized in the axonal compartment over the entire length of the axon in neurons. The mechanisms responsible for the localization of tau in axons at long distance from the cell body are not properly understood. Using fluorescence in situ hybridization, we show that tau mRNA is present in the central and distal parts of the axons of cultured rat cortical neurons. Axonal tau mRNA is associated with granules which are distributed throughout the entire length of the axon, including the growth cone. We also show that tau mRNA-containing axonal particles are associated with elongation factor 1A, a component of the protein translation machinery. The presence of tau mRNA in axons might be at least part of the process by which tau is localized to distal axons.
Uncontrolled Keywords: Axon, Tau, eEF1A, mRNA
Creators: Malmqvist, Tony, Anthony, Karen and Gallo, Jean-Marc
Faculties, Divisions and Institutes: Faculties > Faculty of Health & Society > Sports, Exercise & Life Sciences
Research Centres > Centre for Physical Activity and Life Sciences
Research Centres > Northamptonshire Dementia Research & Innovation Centre
Date: 10 October 2014
Date Type: Publication
Page Range: pp. 22-27
Journal or Publication Title: Brain Research
Volume: 1584
Number of Pages: 6
Language: English
ISSN: 0006-8993
Status: Published / Disseminated
Refereed: Yes

Actions (login required)

Edit Item Edit Item