Northampton Electronic Collection of Theses and Research

Gene variants that predispose to Achilles tendon injuries: an update on recent advances

Raleigh, S. M. and Collins, M. (2012) Gene variants that predispose to Achilles tendon injuries: an update on recent advances. In: Cretnik, A. (ed.) Achilles Tendon. Online: InTech. pp. 25-40.

Item Type: Book Section
Abstract: There are a number of injuries that affect the Achilles tendon and surrounding tissues. Injuries that affect the surrounding tissue include bursitis and paritendonitis, while Achilles tendinopathy and complete or partial ruptures affect the tendon tissues itself (Puddu, 1976) Although injuries to the Achilles tendon are common as a result of individuals in physical activities, Achilles tendon injuries can also occur in sedentary individuals (Young et al, 2005). Although the biological and molecular mechanisms responsible for Achillies tendon injuries are largely unknown, both intrinsic and extrinsic risk factor have nevertheless been implicated in the aetiology of these conditions (Figure 1) (Meeuwisse 1994;Riley,2004;September et al;2006) Genetic usceptibility; which will be the focus of this review, has more recently been included as one of the intrinsic risk factors for chronic Achillies tendinopathy. As illustrated in figure 1, many of the intrinsic risk factor associated with Achillies tendinopathy are in their own right complex phenotypes determined by both genetic and enviromental factors. Flexability (Battie et al, 2008) biological age (Newman et al;2010) muscle strength (Stewart et al;2006),weight (Herrera et al;2010) are all determined by genetic and enviromental factors, the development of the male sex on the other hand is determined genetically (Kousta et al;2010)
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
R Medicine > RB Pathology > RB151 Theories of disease. Etiology. Pathogenesis > RB155 Medical genetics
Creators: Raleigh, Stuart M and Collins, M
Editors: Cretnik, Andrej
Publisher: InTech
Northamptonshire and East Midlands: Health
Faculties, Divisions and Institutes: University Faculties, Divisions and Research Centres - OLD > Faculty of Health & Society
University Faculties, Divisions and Research Centres - OLD > Research Centre > Institute of Health and Wellbeing > Centre for Physical Activity and Chronic Disease
Research Centres > Centre for Health Sciences and Services
Research Centres > Centre for Physical Activity and Life Sciences
Date: 9 March 2012
Date Type: Publication
Page Range: pp. 25-40
Title of Book: Achilles Tendon
Place of Publication: Online
Number of Pages: 144
Language: English
ISBN: 9789535102649
Status: Published / Disseminated

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