Dung cladding of hides presents several problems for processing, but typical soaking enzymes are ineffective for removing dung. This study evaluates the use of appropriate, targeting enzymes in soaking, to effect dung removal from hide. The major components of the composition of dung are lignocellulosic derivatives, cellulose, hemicellulose and lignin, which are the targets. The effects of individual enzymes and enzyme mixtures on dung removal were investigated and it was found that mixtures of cellulase, xylanase and laccase are more effective than individual enzyme treatments. The proposed mechanism for fast dung degradation is based on opening up the structure with lignin and hemicellulose degrading enzymes and breaking down the fibrous structure of cellulose