Northampton Electronic Collection of Theses and Research

Can we improve the statistical analysis of stroke trials? Statistical reanalysis of functional outcomes in stroke trials

Corr, S. (2007) Can we improve the statistical analysis of stroke trials? Statistical reanalysis of functional outcomes in stroke trials. Stroke. 38(6), pp. 1911-1915. 0039-2499.

Item Type: Article
Abstract: Background and Purpose— Most large acute stroke trials have been neutral. Functional outcome is usually analyzed using a yes or no answer, eg, death or dependency versus independence. We assessed which statistical approaches are most efficient in analyzing outcomes from stroke trials. Methods— Individual patient data from acute, rehabilitation and stroke unit trials studying the effects of interventions which alter functional outcome were assessed. Outcomes included modified Rankin Scale, Barthel Index, and "3 questions". Data were analyzed using a variety of approaches which compare 2 treatment groups. The results for each statistical test for each trial were then compared. Results— Data from 55 datasets were obtained (47 trials, 54 173 patients). The test results differed substantially so that approaches which use the ordered nature of functional outcome data (ordinal logistic regression, t test, robust ranks test, bootstrapping the difference in mean rank) were more efficient statistically than those which collapse the data into 2 groups (2; ANOVA, P<0.001). The findings were consistent across different types and sizes of trial and for the different measures of functional outcome. Conclusions— When analyzing functional outcome from stroke trials, statistical tests which use the original ordered data are more efficient and more likely to yield reliable results. Suitable approaches included ordinal logistic regression, t test, and robust ranks test.
Additional Information: This article formed part of the Optimising Analysis of Stroke Trials (OAST) Collaboration
Subjects: R Medicine > RC Internal medicine > RC388.5 Cerebrovascular diseases. Stroke
Creators: Corr, Susan
Publisher: Lippincott, Williams & Wilkins
Faculties, Divisions and Institutes: University Faculties, Divisions and Research Centres - OLD > Faculty of Health & Society > Occupational Therapy
Faculties > Faculty of Health & Society > Occupational Therapy
Date: March 2007
Date Type: Publication
Page Range: pp. 1911-1915
Journal or Publication Title: Stroke
Volume: 38
Number: 6
Language: English
ISSN: 0039-2499
Status: Published / Disseminated
Refereed: Yes

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