Palendira, U., Chinn, R., Raza, W., Piper, K., Pratt, G., Machado, L., Bell, A., Khan, N., Hislop, A., Steyn, R., Rickinson, A., Buckley, C. and Moss, P. (2008) Selective accumulation of virus-specific CD8+ T cells with unique homing phenotype within the human bone marrow. Blood. 112(8), pp. 3293-3302. 0006-4971.
| Item Type: | Article |
|---|---|
| Abstract: | The bone marrow plays a unique role within the immune system. We compared the phenotype and function of virus-specific CD8(+) T cells from matched samples of human peripheral blood and bone marrow. Analysis of virus-specific memory CD8(+) T cells showed widely divergent partition of antigen-specific population between blood and bone marrow. T cells specific for Epstein-Barr virus (EBV) lytic antigens were enriched 3-fold in marrow compared with blood, whereas the response to EBV latent epitopes was equivalent between the 2 compartments. No difference in EBV viral load or expression of the EBV lytic protein was observed between blood and bone marrow. In direct contrast, although cytomegalovirus (CMV)–specific T cells were the largest virus-specific population within peripheral blood, they were reduced by 60% within marrow. Bone marrow T cells were found to exhibit a unique CCR5(+)CXCR6(+)CXCR3(-) homing phenotype which has not been observed on T cells from other secondary lymphoid organs or peripheral organs. Expression of CCR5 and CXCR6 was higher on EBV-specific T cells within peripheral blood compared with CMV-specific populations. These observations identify a novel bone marrow homing phenotype for CD8(+) memory T cells, which necessitates a reevaluation of the magnitude of antigen-specific populations within the lymphoid system. |
| Subjects: |
Q Science > QR Microbiology > QR355 Virology R Medicine > RC Internal medicine > RC633 Diseases of the blood and blood-forming organs Q Science > QR Microbiology > QR180 Immunology |
| Creators: | Palendira, Umaimainthan, Chinn, Rosanna, Raza, Wajid, Piper, Karen, Pratt, Guy, Machado, Lee, Bell, Andrew, Khan, Naeem, Hislop, Andrew, Steyn, Richard, Rickinson, Alan, Buckley, Christopher and Moss, Paul |
| Publisher: | American Society of Hematology |
| Northamptonshire and East Midlands: | Health |
| Faculties, Divisions and Institutes: |
University Faculties, Divisions and Research Centres - OLD > Faculty of Health & Society University Faculties, Divisions and Research Centres - OLD > Research Centre > Institute of Health and Wellbeing > Ageing Research Centre Research Centres > Centre for Health Sciences and Services Research Centres > Centre for Physical Activity and Life Sciences |
| Date: | 15 October 2008 |
| Date Type: | Publication |
| Page Range: | pp. 3293-3302 |
| Journal or Publication Title: | Blood |
| Volume: | 112 |
| Number: | 8 |
| Language: | English |
| DOI: | https://doi.org/10.1182/blood-2008-02-138040 |
| ISSN: | 0006-4971 |
| Status: | Published / Disseminated |
| URI: | http://nectar.northampton.ac.uk/id/eprint/5684 |
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