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Balance features in Alzheimer's disease and amnestic mild cognitive impairment

Leandri, M., Cammisuli, S., Cammarata, S., Baratto, L., Campbell, J., Simonini, M. and Tabaton, M. (2009) Balance features in Alzheimer's disease and amnestic mild cognitive impairment. Journal of Alzheimer's Disease. 16(1), pp. 113-120. 1387-2877.

Item Type: Article
Abstract: We evaluated alterations of balance by stabilometry in patients with amnestic mild cognitive impairment (aMCI) and with mild-moderate Alzheimer's disease (AD). Fifteen patients with aMCI and 15 with mild AD were recruited according to the current diagnostic criteria. Fifteen healthy subjects of the same age range were recruited as controls. Stabilometry was carried out using a commercial 4 load cell platform. Statistical analysis of between group differences was performed using one-way analysis of variance for parametric data and Kruskal-Wallis tests for non-parametric data. Spearman correlation coefficients were used to investigate the association between cognitive test scores and stabilometric data. All stabilometry measures were significantly altered in mild AD patients compared to normal controls. Antero-posterior sway was found to be the most sensitive parameter, since it correlated with the ADAS-cog orientation subscale in AD patients, and also discriminated between aMCI and normal controls. Our study shows that impairment in balance is a feature not only of AD, but also of aMCI. The alterations found suggest that a progressive failure of the vestibular system, possibly linked to reduced hippocampal performance, may be responsible for such a feature. Further research must be focused on studying the predictive value of stabilometry in the conversion of aMCI
Subjects: R Medicine > RC Internal medicine > RC435 Psychiatry > RC553.C64 Cognition disorders
R Medicine > RC Internal medicine > RC435 Psychiatry > RC512 Psychopathology. Mental disorders > RC523 Alzheimer's disease
Creators: Leandri, Massimo, Cammisuli, Sharon, Cammarata, Sergio, Baratto, Luigi, Campbell, Jackie, Simonini, Marina and Tabaton, Massimo
Publisher: IOS Press
Northamptonshire and East Midlands: Health
Faculties, Divisions and Institutes: University Faculties, Divisions and Research Centres - OLD > Faculty of Health & Society
University Faculties, Divisions and Research Centres - OLD > Research Centre > Institute of Health and Wellbeing > Ageing Research Centre
Date: January 2009
Date Type: Publication
Page Range: pp. 113-120
Journal or Publication Title: Journal of Alzheimer's Disease
Volume: 16
Number: 1
Language: English
DOI: https://doi.org/10.3233/JAD-2009-0928
ISSN: 1387-2877
Status: Published / Disseminated
Refereed: Yes
URI: http://nectar.northampton.ac.uk/id/eprint/2045

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