Northampton Electronic Collection of Theses and Research

Engineering extruded collagen fibers for biomedical applications

Zeugolis, D. I., Paul, R. G. and Attenburrow, G. E. (2008) Engineering extruded collagen fibers for biomedical applications. Journal of Applied Polymer Science. 108(5), pp. 2886-2894. 0021-8995.

Item Type: Article
Abstract: Extruded collagen fibers constitute a promising biomimetic scaffold for tissue engineering applications. In this study, we compared the structural, thermal, and mechanical properties of fibers produced from either NaCl or poly(ethylene glycol) with a number-average molecular weight of 8000 (PEG 8K), the only two coagents that have been used in the fabrication process. As novel, we report the fabrication of fibers with properties similar to native or synthetic fibers using other coagents. NaCl derived fibers were characterized by higher thermal stability (p < 0.026), stress (p < 0.001), and modulus (p < 0.0025) values than PEG 8K, whereas the latter yielded more extendable fibers (p < 0.012). Poly(ethylene glycol)s with number-average molecular weights of 200 and 1000 produced fibers with similar mechanical properties (p > 0.05) that were thinner (p < 0.033), stiffer (p < 0.022), and less extendable (p < 0.0002) than those of PEG 8K. Poly(vinyl alcohol) (PVA) with a number-average average molecular weight of 9-10,000 and PEG 8K yielded fibers with similar diameters and stress-at-break values (p > 0.05); however, the poly(ethylene glycol) derived fibers were more extendable (p < 0.0003), whereas the PVA fibers were stiffer (p < 0.029). Gum-arabic- and soluble-starch-derived fibers were of similar tensile strength, extendibility, and stiffness (p > 0.05). In this in vitro study, the thickest (p < 0.011) and the weakest (p < 0.0066) fibers were produced in the presence of sodium sulfate
Uncontrolled Keywords: biodegradable, biofibers, biomaterial, extrusion, mechanical properties
Subjects: R Medicine > R Medicine (General) > R856 Biomedical engineering. Electronics. Instrumentation.
T Technology > TP Chemical technology > TP248.13 Biotechnology
Q Science > QP Physiology > QP501 Animal biochemistry > QP552.C6 Collagen
Creators: Zeugolis, D I, Paul, R G and Attenburrow, Geoff E
Publisher: John Wiley & Sons
Faculties, Divisions and Institutes: University Faculties, Divisions and Research Centres - OLD > Research Centre > Centre for Research on Leather and Materials Science
Research Institutes > Institute for Creative Leather Technologies
Date: 2008
Date Type: Publication
Page Range: pp. 2886-2894
Journal or Publication Title: Journal of Applied Polymer Science
Volume: 108
Number: 5
Language: English
ISSN: 0021-8995
Status: Published / Disseminated
Refereed: Yes

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