Duchenne muscular dystrophy gene expression is an independent prognostic marker for IDH mutant low-grade glioma

Naidoo, M., Jones, L., Conboy, B., Hamarneh, W., D'Souza, D., Anthony, K. and Machado, L. (2022) Duchenne muscular dystrophy gene expression is an independent prognostic marker for IDH mutant low-grade glioma. Poster presented to: Cancer Research UK Brain Tumour Conference, 2022-09-05 - 2022-09-07.

Naidoo_etal_2022_Duchenne_muscular_dystrophy_gene_expression_is_an_independent_prognostic_marker_for_IDH_m ... (822kB)

Item Type:	Conference or Workshop Item (Poster)
Abstract:	The Duchenne muscular dystrophy (DMD) gene is the largest known human gene spanning a genomic range over 2Mb. It encodes multiple protein products of varying size and function. Several studies have emerged showing that muscular dystrophy mouse models are prone to develop spontaneous soft tissue sarcomas (STS). High DMD expression has been linked to several cancers, including low-grade glioma (LGG), improving prognosis in some and worsening prognosis in others. Although literature has previously linked the DMD gene to numerous cancers, none have considered the many gene products produced by the DMD gene. Dp71 is a ubiquitous dystrophin protein and the predominant DMD product in the brain.
Uncontrolled Keywords:	/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Creators:	Naidoo, Michael, Jones, Leanne, Conboy, Benjamin, Hamarneh, Wael, D'Souza, Darwin, Anthony, Karen and Machado, Lee
Faculties, Divisions and Institutes:	?? ASSCI ?? Research Centres > Centre for Physical Activity and Life Sciences
Date:	5 September 2022
Date Type:	Publication
Journal or Publication Title:	Cancer Research UK Brain Tumour Conference
Event Title:	Cancer Research UK Brain Tumour Conference
Event Dates:	2022-09-05 - 2022-09-07
Place of Publication:	London
Event Type:	Other
Number of Pages:	1
Language:	English
Status:	Published / Disseminated
Refereed:	Yes
Related URLs:	https://pure.northampton.ac.uk/en/public...
URI:	http://nectar.northampton.ac.uk/id/eprint/17617

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