G.P.228 - Micro RNA profile associated with the dystrophin level in Becker muscular dystrophy

Zaharieva, I., Cirak, S., Anthony, K., Feng, L., Tasca, G., Ferlini, A., Morgan, J. and Muntoni, F. (2015) G.P.228 - Micro RNA profile associated with the dystrophin level in Becker muscular dystrophy. Neuromuscular Disorders. 25(Supp 2) 0960-8966.

Zaharieva_NM_2015_G.P.228_Micro_ RNA_profile_associated_with_the_dystrophin_level_in_Becker_muscular_dystr ... (76kB)

Item Type:	Article
Abstract:	Becker (BMD) and Duchenne muscular dystrophy (DMD) are allelic disorders arising from mutations in the dystrophin gene. In-frame mutations lead to the milder BMD while out-of-frame mutations disrupt the reading frame and lead to the severe DMD with lack of dystrophin. A therapeutic strategy for skipping specific exons in dystrophin and restoring the open reading frame has been successfully applied in DMD; this “converts” the out-of-frame deletion in DMD to BMD-like in-frame deletion. Micro RNAs (miRs) are small RNA sequences that regulate gene expression post-transcriptionally.
Creators:	Zaharieva, I, Cirak, S, Anthony, Karen, Feng, L, Tasca, G, Ferlini, A, Morgan, J and Muntoni, F
Faculties, Divisions and Institutes:	Research Centres > Centre for Physical Activity and Life Sciences Faculties > Faculty of Health & Society > Sports, Exercise & Life Sciences Research Centres > Northamptonshire Dementia Research & Innovation Centre
Date:	1 October 2015
Date Type:	Publication
Journal or Publication Title:	Neuromuscular Disorders
Volume:	25
Number:	Supp 2
Language:	English
ISSN:	0960-8966
Status:	Published / Disseminated
Refereed:	Yes
Related URLs:	https://pure.northampton.ac.uk/en/public...
URI:	http://nectar.northampton.ac.uk/id/eprint/11659

Actions (login required)

Edit Item

Altmetric