Copy number variation of Fc gamma receptor genes in HIV-infected and HIV-tuberculosis co-infected individuals in Sub-Saharan Africa

Machado, L., Bowdrey, J., Ngaimisi, E., Habtewold, A., Minzi, O., Makonnen, E., Yimer, G., Amogne, W., Mugusi, S., Janabi, M., Aderaye, G., Mugusi, F., Viskaduraki, M., Aklillu, E. and Hollox, E. J. (2013) Copy number variation of Fc gamma receptor genes in HIV-infected and HIV-tuberculosis co-infected individuals in Sub-Saharan Africa. PLoS ONE. 8(11) 1932-6203.

Texts
Information

[A][B][+][-]

6100:7608

[A][B][+][-]

6100:7608

Machado20136100.pdf - Published Version
Available under License Creative Commons Attribution.

Information

Abstract:

AIDS, caused by the retrovirus HIV, remains the largest cause of morbidity in sub-Saharan Africa yet almost all genetic studies have focused on cohorts from Western countries. HIV shows high co-morbidity with tuberculosis (TB), as HIV stimulates the reactivation of latent tuberculosis (TB). Recent clinical trials suggest that an effective anti-HIV response correlates with non-neutralising antibodies. Given that Fcγ receptors are critical in mediating the nonneutralising effects of antibodies, analysis of the extensive variation at Fcγ receptor genes is important. Single nucleotide variation and copy number variation (CNV) of Fcγ receptor genes affects the expression profile, activatory/inhibitory balance, and IgG affinity of the Fcγ receptor repertoire of each individual. In this study we investigated whether CNV of FCGR2C, FCGR3A and FCGR3B as well as the HNA1 allotype of FCGR3B is associated with HIV load, response to highly-active antiretroviral therapy (HAART) and co-infection with TB. We confirmed an effect of TB-co-infection status on HIV load and response to HAART, but no conclusive effect of the genetic variants we tested. We observed a small effect, in Ethiopians, of FCGR3B copy number, where deletion was more frequent in HIV-TB co-infected patients than those infected with HIV alone.

Uncontrolled Keywords:

/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being

Creators:

Machado, L., Bowdrey, J., Ngaimisi, E., Habtewold, A., Minzi, O., Makonnen, E., Yimer, G., Amogne, W., Mugusi, S., Janabi, M., Aderaye, G., Mugusi, F., Viskaduraki, M., Aklillu, E. and Hollox, E. J.

Faculties, Divisions and Institutes:

Faculties > Faculty of Health & Society > Sports, Exercise & Life Sciences
Research Centres > Centre for Physical Activity and Life Sciences

Date:

1 November 2013

Date Type:

Publication

Journal or Publication Title:

PLoS ONE

Volume:

Number:

Language:

English