Posthumus, M., Raleigh, S. M., Ribbans, W. J., Schwellnus, M. P. and Collins, M. (2010) A functional variant within the MMP3 gene does not associate with human range of motion. Journal of Science and Medicine in Sport. 13(6), pp. 630-632. 1440-2440.
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Abstract:
A recent heritability study has demonstrated that human range of motion (ROM) has a substantial genetic component. Furthermore, the COL5A1BstUI RFLP has now been identified as the first gene variant to be associated with human ROM. Interestingly, this variant is known to interact with a functional variant within the MMP3 gene (rs679620) to increase risk of Achilles tendinopathy. We sought to determine whether the MMP3 rs679620 variant was associated with ROM both as a single marker and as an interacting marker with the COL5A1 BstUI RFLP. One hundred and twenty one participants were included in this study. All participants were genotyped for the MMP3 rs679620 variant, and performed passive straight leg raise (SLR) and sit and reach (SR) measurements. There were no significant differences in left leg SLR (L-SLR), right leg SLR (R-SLR), or SR measurements between the genotype groups (L-SLR, P=0.494; R-SLR, P=0.435; SR, P=0.266). Furthermore, there was no evidence of an interaction between the COL5A1 BstUI RFLP and the MMP3 rs679620 variant. Our study suggests that the MMP3 rs679620 variant does not associate with passive ROM.
Subjects:
Creators:
Posthumus, M., Raleigh, S. M., Ribbans, W. J., Schwellnus, M. P. and Collins, M.
Publisher:
Sports Medicine Australia
Faculties, Divisions and Institutes:
University Faculties, Divisions and Research Centres - OLD > Faculty of Health & Society > Sports, Exercise & Life Sciences
University Faculties, Divisions and Research Centres - OLD > Research Centre > Institute of Health and Wellbeing > Centre for Physical Activity and Chronic Disease
Faculties > Faculty of Health & Society > Sports, Exercise & Life Sciences
Research Centres > Centre for Health Sciences and Services
Research Centres > Centre for Physical Activity and Life Sciences
University Faculties, Divisions and Research Centres - OLD > Research Centre > Institute of Health and Wellbeing > Centre for Physical Activity and Chronic Disease
Faculties > Faculty of Health & Society > Sports, Exercise & Life Sciences
Research Centres > Centre for Health Sciences and Services
Research Centres > Centre for Physical Activity and Life Sciences
Date:
November 2010
Date Type:
Publication
Page Range:
pp. 630-632
Journal or Publication Title:
Journal of Science and Medicine in Sport
Volume:
13
Number:
6
Language:
English
ISSN:
1440-2440
Status:
Published / Disseminated
Refereed:
Yes
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