Evaluation of gas chromatography mass spectrometry and pattern recognition for the identification of bladder cancer from urine headspace

Cauchi, M., Weber, C. M., Bolt, B. J., Spratt, P. B., Bessant, C., Turner, D. C., Willis, C. M., Britton, L. E., Turner, C. and Morgan, G. (2016) Evaluation of gas chromatography mass spectrometry and pattern recognition for the identification of bladder cancer from urine headspace. Analytical Methods. 8, pp. 4037-4046. 1759-9660.

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20762:62694

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20762:62694

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Cauchi_et_al_2016_Evaluation_of_gas_chromatography_mass_spectrometry_and_pattern_recognition_for_the_identification_of_bladder_cancer_from_urine_headspace
Cauchi_et_al_2016_Evaluation_of_gas_chromatography_mass_spectrometry_and_pattern_recognition_for_the_identification_of_bladder_cancer_from_urine_headspace.pdf - Published Version
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Abstract:

Previous studies have indicated that volatile organic compounds specific to bladder cancer may exist in urine headspace, raising the possibility that they may be of diagnostic value for this particular cancer. To further examine this hypothesis, urine samples were collected from patients diagnosed with either bladder cancer or a non-cancerous urological disease/infection, and from healthy volunteers, from which the volatile metabolomes were analysed using gas chromatography mass spectrometry. The acquired data were subjected to a specifically designed pattern recognition algorithm, involving cross-model validation. The best diagnostic performance, achieved with independent test data provided by healthy volunteers and bladder cancer patients, was 89% overall accuracy (90% sensitivity and 88% specificity). Permutation tests showed that these were statistically significant, providing further evidence of the potential for volatile biomarkers to form the basis of a non-invasive diagnostic technique.

Additional Information:

The authors would like to thank the staff of the Urology Department, Buckinghamshire Healthcare NHS Trust for their enthusiastic support.

Uncontrolled Keywords:

/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being

Creators:

Cauchi, M., Weber, C. M., Bolt, B. J., Spratt, P. B., Bessant, C., Turner, D. C., Willis, C. M., Britton, L. E., Turner, C. and Morgan, G.

Date:

3 May 2016

Date Type:

Publication

Page Range:

pp. 4037-4046

Journal or Publication Title:

Analytical Methods

Volume:

Language:

English

ISSN:

1759-9660

Status:

Published / Disseminated

Refereed:

Yes