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A systematic literature review and meta-analysis of the effectiveness of vitamin D supplementation for patients with Duchenne muscular dystrophy

Guo, J. and Anthony, K. (2023) A systematic literature review and meta-analysis of the effectiveness of vitamin D supplementation for patients with Duchenne muscular dystrophy. Neuromuscular Disorders. 33(11), pp. 835-844. 0960-8966.

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Guo_etal_Elsevier_2023_A_systematic_literature_review_and_meta-analysis_of_the_effectiveness_of_vitamin_D_supplementation_for_patients_with_Duchenne_muscular_dystrophy
Guo_etal_Elsevier_2023_A_systematic_literature_review_and_meta-analysis_of_the_effectiveness_of_vitamin_D_supplementation_for_patients_with_Duchenne_muscular_dystrophy.pdf - Accepted Version
Available under License Creative Commons Attribution.
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Abstract:
We conducted a systematic literature review and meta-analysis on the effectiveness of vitamin D supplementation in maintaining or restoring vitamin D levels in Duchenne muscular dystrophy. Due to a lack of randomised controlled trials, cross-sectional and retrospective and prospective cohort studies were taken as the best available evidence. Inclusion criteria included reporting mean serum vitamin D levels in a supplement-taking group. After screening 102 records; 13 were included in a narrative synthesis and eight of these in a meta-analysis. We show that current dosing regimens are preventing severe deficiency but are not effective at maintaining sufficient vitamin D levels within the Duchenne population. Despite high levels of daily vitamin D supplementation (>1000 International Units), at least 20% of people with Duchenne remain vitamin D deficient. No significant association between dose and serum vitamin D levels was found (r2 = 0.3, p = 0.237). A meta-analysis of mean serum vitamin D levels across eight studies also revealed substantial variability in response to vitamin D supplementation and high heterogeneity (I2 = 99.59 %). These data could impact on an individual's risk and severity of osteoporosis and vertebral fractures.
Additional Information:
©2023. This manuscript version is made available under the CC-BY 4.0 license https://creativecommons.org/licenses/by/4.0/
Uncontrolled Keywords:
/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Creators:
Guo, J. and Anthony, K.
Faculties, Divisions and Institutes:
?? ASSCI ??
Research Centres > Centre for Physical Activity and Life Sciences
Research Centres > Northamptonshire Dementia Research & Innovation Centre
Date:
15 October 2023
Date Type:
Publication
Page Range:
pp. 835-844
Journal or Publication Title:
Neuromuscular Disorders
Volume:
33
Number:
11
Number of Pages:
10
Language:
English
ISSN:
0960-8966
Status:
Published / Disseminated
Refereed:
Yes
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