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Tendon and Ligament Genetics: How Do They Contribute to Disease and Injury? A Narrative Review

Ribbans, B., September, A. V. and Collins, M. (2022) Tendon and Ligament Genetics: How Do They Contribute to Disease and Injury? A Narrative Review. Life. 12(5) 2075-1729.

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16595:35839
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Ribbans_etal_Life_2022_Tendon_and_Ligament_Genetics_How_Do_They_Contribute_to_Disease_and_Injury_A_Narrative_Review.pdf - Published Version
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Information
Abstract:
A significant proportion of patients requiring musculoskeletal management present with tendon and ligament pathology. Our understanding of the intrinsic and extrinsic mechanisms that lead to such disabilities is increasing. However, the complexity underpinning these interactive multifactorial elements is still not fully characterised. Evidence highlighting the genetic components, either reducing or increasing susceptibility to injury, is increasing. This review examines the present understanding of the role genetic variations contribute to tendon and ligament injury risk. It examines the different elements of tendon and ligament structure and considers our knowledge of genetic influence on form, function, ability to withstand load, and undertake repair or regeneration. The role of epigenetic factors in modifying gene expression in these structures is also explored. It considers the challenges to interpreting present knowledge, the requirements, and likely pathways for future research, and whether such information has reached the point of clinical utility.
Uncontrolled Keywords:
Ecology, Evolution, Behavior and Systematics, General Biochemistry, Genetics and Molecular Biology, Paleontology, Space and Planetary Science
Creators:
Ribbans, B., September, A. V. and Collins, M.
Faculties, Divisions and Institutes:
?? ASSCI ??
Research Centres > Centre for Physical Activity and Life Sciences
Faculties > Faculty of Health & Society > Sports, Exercise & Life Sciences
Date:
29 April 2022
Date Type:
Publication
Journal or Publication Title:
Life
Volume:
12
Number:
5
Number of Pages:
36
Language:
English
DOI:
10.3390/life12050663
ISSN:
2075-1729
Status:
Published / Disseminated
Refereed:
Yes
Related URLs:
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