Northampton Electronic Collection of Theses and Research

RNA-based therapeutics for neurological diseases

Anthony, K. (2022) RNA-based therapeutics for neurological diseases. RNA Biology. 19(1), pp. 176-190. 1547-6286.

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Anthony_Karen_RNAB_2022_RNA_based_therapeutics_for_neurological_diseases.pdf - Published Version
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Abstract:
RNA-based therapeutics have entered the mainstream with seemingly limitless possibilities to treat all categories of neurological disease. Here, common RNA-based drug modalities such as antisense oligonucleotides, small interfering RNAs, RNA aptamers, RNA-based vaccines and mRNA drugs are reviewed highlighting their current and potential applications. Rapid progress has been made across rare genetic diseases and neurodegenerative disorders, but safe and effective delivery to the brain remains a significant challenge for many applications. The advent of individualised RNA-based therapies for ultra-rare diseases is discussed against the backdrop of the emergence of this field into more common conditions such as Alzheimer’s disease and ischaemic stroke. There remains significant untapped potential in the use of RNA-based therapeutics for behavioural disorders and tumours of the central nervous system; coupled with the accelerated development expected over the next decade, the true potential of RNA-based therapeutics to transform the therapeutic landscape in neurology remains to be uncovered.
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2800/2808
Creators:
Anthony, K.
Faculties, Divisions and Institutes:
?? ASSCI ??
Research Centres > Centre for Physical Activity and Life Sciences
Research Centres > Northamptonshire Dementia Research & Innovation Centre
Date:
22 January 2022
Date Type:
Publication
Page Range:
pp. 176-190
Journal or Publication Title:
RNA Biology
Volume:
19
Number:
1
Number of Pages:
15
Language:
English
DOI:
10.1080/15476286.2021.2021650
ISSN:
1547-6286
Status:
Published / Disseminated
Refereed:
Yes
Related URLs:
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