Pregnancy rates after slow-release insemination (SRI) and standard bolus intrauterine insemination (IUI) – A multicentre randomised, controlled trial

Marschalek, J., Egarter, C., Vytiska-Binsdorfer, E., Obruca, A., Campbell, J., Harris, P., van Santen, M., Lesoine, B., Ott, J. and Franz, M. (2020) Pregnancy rates after slow-release insemination (SRI) and standard bolus intrauterine insemination (IUI) – A multicentre randomised, controlled trial. Scientific Reports. 10(1) 2045-2322.

Texts
Information

[A][B][+][-]

12869:28974

[A][B][+][-]

12869:28974

[thumbnail of Marschalek et al_SRI_RCT_]

Marschalek et al_SRI_RCT_
Marschalek_et_al_SRI_RCT_.pdf - Published Version
Available under License Creative Commons Attribution.

Information

Abstract:

Abstract: This multicentre, randomised, controlled cross-over trial was designed to investigate the effect of intra-uterine slow-release insemination (SRI) on pregnancy rates in women with confirmed infertility or the need for semen donation who were eligible for standard bolus intra-uterine insemination (IUI). Data for a total of 182 women were analysed after randomisation to receive IUI (n = 96) or SRI (n = 86) first. The primary outcome was serological pregnancy defined by a positive beta human chorionic gonadotropin test, two weeks after insemination. Patients who did not conceive after the first cycle switched to the alternative technique for the second cycle: 44 women switched to IUI and 58 switched to SRI. In total, there were 284 treatment cycles (IUI: n = 140; SRI: n = 144). Pregnancy rates following SRI and IUI were 13.2% and 10.0%, respectively, which was not statistically significant (p = 0.202). A statistically significant difference in pregnancy rates for SRI versus IUI was detected in women aged under 35 years. In this subgroup, the pregnancy rate with SRI was 17% compared to 7% with IUI (relative risk 2.33; p = 0.032) across both cycles. These results support the hypothesis that the pregnancy rate might be improved with SRI compared to standard bolus IUI, especially in women aged under 35 years.

Creators:

Marschalek, J., Egarter, C., Vytiska-Binsdorfer, E., Obruca, A., Campbell, J., Harris, P., van Santen, M., Lesoine, B., Ott, J. and Franz, M.

Faculties, Divisions and Institutes:

?? HSRES ??

Date:

7 May 2020

Date Type:

Publication

Journal or Publication Title:

Scientific Reports

Volume:

Number:

Number of Pages:

Language:

English

DOI:

10.1038/s41598-020-64164-4

ISSN:

2045-2322

Status:

Published / Disseminated

Refereed:

Yes

Related URLs: