Tau mRNA is present in axonal RNA granules and is associated with elongation factor 1A

Malmqvist, T., Anthony, K. and Gallo, J.-M. (2014) Tau mRNA is present in axonal RNA granules and is associated with elongation factor 1A. Brain Research. 1584, pp. 22-27. 0006-8993.

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Micke's paper TauRNA_KA
Micke_s_paper_TauRNA_KA.docx - Draft Version

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Abstract:

The microtubule-associated protein tau is predominantly localized in the axonal compartment over the entire length of the axon in neurons. The mechanisms responsible for the localization of tau in axons at long distance from the cell body are not properly understood. Using fluorescence in situ hybridization, we show that tau mRNA is present in the central and distal parts of the axons of cultured rat cortical neurons. Axonal tau mRNA is associated with granules which are distributed throughout the entire length of the axon, including the growth cone. We also show that tau mRNA-containing axonal particles are associated with elongation factor 1A, a component of the protein translation machinery. The presence of tau mRNA in axons might be at least part of the process by which tau is localized to distal axons.

Uncontrolled Keywords:

Axon, Tau, eEF1A, mRNA

Creators:

Malmqvist, T., Anthony, K. and Gallo, J.-M.

Faculties, Divisions and Institutes:

Faculties > Faculty of Health & Society > Sports, Exercise & Life Sciences
Research Centres > Centre for Physical Activity and Life Sciences

Date:

10 October 2014

Date Type:

Publication

Page Range:

pp. 22-27

Journal or Publication Title:

Brain Research

Volume:

1584

Number of Pages:

Language:

English

DOI:

10.1016/j.brainres.2013.12.033

ISSN:

0006-8993

Status:

Published / Disseminated

Refereed:

Yes