Raleigh, S. M., Posthumus, M., O'Cuinneagain, D., van der Merwe, W. and Collins, M. (2013) The GDF5 gene and anterior cruciate ligament rupture. International Journal of Sports Medicine. 34(4), pp. 364-367. 0172-4622.
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Abstract:
A recent genetic association study has revealed that a variant (rs143383) within the 5′-untranslated region of the growth differentiation factor 5 gene (GDF5) associates with the risk of Achilles tendon pathology. The aim of this study was to determine whether this variant associates with the risk of ACL rupture. A cohort of 126 Caucasians with ACL rupture (ACL group), including 51 subjects who ruptured their ACL through a noncontact mechanism (NON sub-group), and 214 controls (CON group) were genotyped for the rs143383 variant. We report no significant GDF5 rs143383 genotype (P = 0.396) or allele (P = 0.810) frequency differences between the ACL (TT genotype, n = 37, 29 %; CT genotype, n = 72, 57 %; CC genotype, n = 17, 14 %) and CON (TT genotype, n = 73, 34 %; CT genotype, n = 106, 50 %; CC genotype, n = 35, 16 %) groups. There were also no significant differences between the NON sub-group and the CON group (allele; P = 0.710, genotype; P = 0.771). Furthermore, in gender specific analysis we found no association between rs143383 and ACL in either males (allele; P = 0.988, genotype; P = 0.407) or females (allele; P = 0.643, genotype; P = 0.885), respectively. Nor were there any gender specific associations between the NON sub-group and either genotype or allele. In conclusion, the rs143383 variant was not found to associate with the risk of ACL rupture.
Uncontrolled Keywords:
genotype, ACL, rupture, GDF5
Subjects:
Creators:
Raleigh, S. M., Posthumus, M., O'Cuinneagain, D., van der Merwe, W. and Collins, M.
Publisher:
Thieme
Northamptonshire and East Midlands:
Health
Faculties, Divisions and Institutes:
University Faculties, Divisions and Research Centres - OLD > Faculty of Health & Society > Sports, Exercise & Life Sciences
University Faculties, Divisions and Research Centres - OLD > Research Centre > Institute of Health and Wellbeing > Centre for Physical Activity and Chronic Disease
Faculties > Faculty of Health & Society > Sports, Exercise & Life Sciences
Research Centres > Centre for Health Sciences and Services
Research Centres > Centre for Physical Activity and Life Sciences
University Faculties, Divisions and Research Centres - OLD > Research Centre > Institute of Health and Wellbeing > Centre for Physical Activity and Chronic Disease
Faculties > Faculty of Health & Society > Sports, Exercise & Life Sciences
Research Centres > Centre for Health Sciences and Services
Research Centres > Centre for Physical Activity and Life Sciences
Date:
April 2013
Date Type:
Publication
Page Range:
pp. 364-367
Journal or Publication Title:
International Journal of Sports Medicine
Volume:
34
Number:
4
Language:
English
ISSN:
0172-4622
Status:
Published / Disseminated
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