Raleigh, S. M., Posthumus, M., O'Cuinneagain, D., van der Merwe, W. and Collins, M. (2013) The GDF5 gene and anterior cruciate ligament rupture. International Journal of Sports Medicine. 34(4), pp. 364-367. 0172-4622.
| Item Type: | Article |
|---|---|
| Abstract: | A recent genetic association study has revealed that a variant (rs143383) within the 5′-untranslated region of the growth differentiation factor 5 gene (GDF5) associates with the risk of Achilles tendon pathology. The aim of this study was to determine whether this variant associates with the risk of ACL rupture. A cohort of 126 Caucasians with ACL rupture (ACL group), including 51 subjects who ruptured their ACL through a noncontact mechanism (NON sub-group), and 214 controls (CON group) were genotyped for the rs143383 variant. We report no significant GDF5 rs143383 genotype (P = 0.396) or allele (P = 0.810) frequency differences between the ACL (TT genotype, n = 37, 29 %; CT genotype, n = 72, 57 %; CC genotype, n = 17, 14 %) and CON (TT genotype, n = 73, 34 %; CT genotype, n = 106, 50 %; CC genotype, n = 35, 16 %) groups. There were also no significant differences between the NON sub-group and the CON group (allele; P = 0.710, genotype; P = 0.771). Furthermore, in gender specific analysis we found no association between rs143383 and ACL in either males (allele; P = 0.988, genotype; P = 0.407) or females (allele; P = 0.643, genotype; P = 0.885), respectively. Nor were there any gender specific associations between the NON sub-group and either genotype or allele. In conclusion, the rs143383 variant was not found to associate with the risk of ACL rupture. |
| Uncontrolled Keywords: | genotype, ACL, rupture, GDF5 |
| Subjects: |
R Medicine > RC Internal medicine > RC1200 Sports Medicine R Medicine > RB Pathology > RB151 Theories of disease. Etiology. Pathogenesis > RB155 Medical genetics |
| Creators: | Raleigh, Stuart M, Posthumus, Michael, O'Cuinneagain, D, van der Merwe, W and Collins, M |
| Publisher: | Thieme |
| Northamptonshire and East Midlands: | Health |
| Faculties, Divisions and Institutes: |
University Faculties, Divisions and Research Centres - OLD > Faculty of Health & Society > Sports, Exercise & Life Sciences University Faculties, Divisions and Research Centres - OLD > Research Centre > Institute of Health and Wellbeing > Centre for Physical Activity and Chronic Disease Faculties > Faculty of Health & Society > Sports, Exercise & Life Sciences Research Centres > Centre for Health Sciences and Services Research Centres > Centre for Physical Activity and Life Sciences |
| Date: | April 2013 |
| Date Type: | Publication |
| Page Range: | pp. 364-367 |
| Journal or Publication Title: | International Journal of Sports Medicine |
| Volume: | 34 |
| Number: | 4 |
| Language: | English |
| DOI: | https://doi.org/10.1055/s-0032-1316361 |
| ISSN: | 0172-4622 |
| Status: | Published / Disseminated |
| URI: | http://nectar.northampton.ac.uk/id/eprint/5189 |
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