Ryan, D., Wullems, J., Stebbings, G., Morse, C., Stewart, C. and Onambele-Pearson, G. (2019) Using isotemporal substitution to predict the effects of changing physical behaviour on older adults’ cardio-metabolic profiles. PLoS ONE. 14(10) 1932-6203.
| Item Type: | Article |
|---|---|
| Abstract: | BACKGROUND: It has been advocated that older adults should concomitantly spend less time in sedentary behaviour (SB), and engage in sufficient physical activity (PA), to reduce their risk of cardio-metabolic diseases. However, it is not clear what intensity of PA must be done to offset SB engagement. AIM: Model how cardio-metabolic profiles could change if older adults replaced an hour per day (hr·day-1) of a physical behaviour intensity with 1 hr·day-1 of another physical behaviour of a different intensity. METHODS: Older adults (n = 93, 60-89 years old, 55% female) wore a thigh-mounted triaxial accelerometer for seven consecutive free-living days to estimate mean daily hourly engagement in SB, Standing, Light Intensity PA (LIPA), sporadic moderate to vigorous physical activity (sMVPA, bouts <10 continuous minutes), and 10-minute MVPA (10MVPA, bouts ≥10 continuous minutes. Fasting whole blood concentration of plasma glucose, triglyceride, total cholesterol, and glycated haemoglobin (%), along with serum concentration of lipoprotein lipase (LPL), interleukin-6 (IL-6), and procollagen III N-terminal propeptide (PIIINP) were measured. RESULTS: Isotemporal Substitution, with covariate adjustment, suggested that: total cholesterol concentration could theoretically decrease when 1 hr·day-1 of SB is replaced with Standing, when 1 hr.day-1 of LIPA is replaced with Standing, and when 1 hr·day-1 of sMVPA is replaced with Standing. Triglyceride concentration theoretically decreased when 1 hr·day-1 of SB, Standing, LIPA, or sMVPA is replaced with 10MVPA. Triglyceride concentration theoretically increases when 1 hr·day-1 of 10MVPA is replaced with SB, Standing, or LIPA. No associations with time reallocation appears to exist for LPL, HbA1c, IL-6, and PIIINP. CONCLUSION: The type of physical behaviour being replaced could be crucial for total cholesterol maintenance. Engagement in 10MVPA could be necessary to improve triglyceride concentration. |
| Uncontrolled Keywords: | General Agricultural and Biological Sciences, General Biochemistry, Genetics and Molecular Biology, General Medicine |
| Creators: | Ryan, Declan, Wullems, Jorgen, Stebbings, Georgina, Morse, Christopher, Stewart, Claire and Onambele-Pearson, Gladys |
| Faculties, Divisions and Institutes: |
?? ASSCI ?? Research Centres > Centre for Physical Activity and Life Sciences |
| Date: | 23 October 2019 |
| Date Type: | Publication |
| Journal or Publication Title: | PLoS ONE |
| Volume: | 14 |
| Number: | 10 |
| Number of Pages: | 14 |
| Language: | English |
| DOI: | https://doi.org/10.1371/journal.pone.0224223 |
| ISSN: | 1932-6203 |
| Status: | Published / Disseminated |
| Refereed: | Yes |
| Related URLs: | |
| URI: | http://nectar.northampton.ac.uk/id/eprint/12239 |
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