Northampton Electronic Collection of Theses and Research

Microscopic examination of skin structure

Wertheim, D., Covington, A. D., Petford, N., Murray, T. and Antunes, A. P. M. (2014) Microscopic examination of skin structure. International Journal of Clinical & Medical Imaging. 1(1) 2376-0249.

Item Type: Article
Abstract: Microscopic examination of the skin structure may help in identifying possible lesions as well as studying the integrity of the tissue; two dimensional examination of the structure may not be able to easily identify the complexity of the collagen bundle network in skin sections. In this area our research involves examination of skin sections in three dimensions. Thin dermal sections were stained with Haematoxylin and Eosin (H & E) and mounted on glass slides with a cover slip. The sections were imaged using a Leica TCS SP2 confocal microscope (Leica Microsystems GmbH, Germany). We have developed software techniques for 3D visualisation of the confocal data allowing display on a computer monitor or an observation cube. The image shows an example of visualisation from confocal microscope data of collagen bundles in a skin section (microscope image width 750 microns).
Subjects: Q Science > QD Chemistry > QD415 Biochemistry
Q Science > QH Natural history > QH201 Microscopy
Creators: Wertheim, D, Covington, Anthony D, Petford, Nick, Murray, Tom and Antunes, A Paula M
Publisher: OMICS Publishing Group
Faculties, Divisions and Institutes: Faculties > Faculty of Arts, Science & Technology > Computing
Date: 1 January 2014
Date Type: Publication
Journal or Publication Title: International Journal of Clinical & Medical Imaging
Volume: 1
Number: 1
Language: English
ISSN: 2376-0249
Status: Published / Disseminated
Refereed: Yes
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