Parsonage, G., Machado, L., Hui, J. W.-Y., Schmaler, T. T., Balasothy, M., Van Hasselt, A., Vlantis, L., Hui, E. P., Chan, A. T. C., Lo, K.-W. and Lee, S. P. (2010) T cell homing to nasopharyngeal carcinoma. Poster presented to: 14th Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases, University of Birmingham, 04-07 September 2010. (Unpublished)
| Item Type: | Conference or Workshop Item (Poster) |
|---|---|
| Abstract: | Undifferentiated nasopharyngeal carcinoma (NPC) is a very good candidate disease for treatment with adoptive T cell transfer. Uniformly Epstein-Barr virus (EBV)+, these tumours reportedly have functional antigen processing and presentation machinery and express viral proteins that contain known cytolytic T cell target epitopes. This raises the possibility that boosting relevant EBV-specific T cell immunity in NPC patients might defeat the tumour. The persistent nature of EBV infection may also encourage the long-term survival of therapeutically administered virus-specific cells. However, efficient delivery of tumour-specific T cells from the circulation to solid tumour tissue is a clear requirement for effective cellular therapy, yet the mechanisms by which T cells gain entry to NPC tumours have not yet been determined. The malignant cells of NPC are usually associated with a substantial lymphoid infiltrate mainly consisting of T cells. Using unmanipulated diagnostic biopsy samples, we have characterised chemokine receptor expression (CR) on tumour-infiltrating T cells, and established whether specific chemokine ligands are detectable at the NPC tumour site. We found that functional CXCR6 and CCR5 were expressed on tumour infiltrating T cells, consistent with the presence of specific ligands for these receptors at the tumour site. Furthermore, our data suggests that effector and regulatory cells may use shared homing mechanisms to gain entry to NPC tumours. |
| Subjects: |
Q Science > QR Microbiology > QR355 Virology R Medicine > RC Internal medicine > RC254 Neoplasms. Tumors. Oncology R Medicine > RM Therapeutics. Pharmacology > RM270 Immunotherapy. Serotherapy |
| Creators: | Parsonage, Greg, Machado, Lee, Hui, Jan Wai-Ying, Schmaler, Tilo T, Balasothy, Meenarani, Van Hasselt, Andrew, Vlantis, Lex, Hui, Edwin Pun, Chan, Anthony T C, Lo, Kwok-Wai and Lee, S P |
| Northamptonshire and East Midlands: | Health |
| Faculties, Divisions and Institutes: |
University Faculties, Divisions and Research Centres - OLD > Faculty of Health & Society > Sports, Exercise & Life Sciences University Faculties, Divisions and Research Centres - OLD > Research Centre > Institute of Health and Wellbeing > Ageing Research Centre Faculties > Faculty of Health & Society > Sports, Exercise & Life Sciences Research Centres > Centre for Health Sciences and Services Research Centres > Centre for Physical Activity and Life Sciences |
| Date: | 2010 |
| Date Type: | Presentation |
| Event Title: | 14th Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases |
| Event Dates: | 04-07 September 2010 |
| Event Location: | University of Birmingham |
| Event Type: | Conference |
| Language: | English |
| Status: | Unpublished |
| URI: | http://nectar.northampton.ac.uk/id/eprint/6854 |
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