Northampton Electronic Collection of Theses and Research

A computational model of acute pain

Prince, K., Campbell, J., Picton, P. and Turner, S. J. (2004) A computational model of acute pain. In: Horton, G. (ed.) Proceedings 18th European Simulation Multiconference. Erlangen, Germany: SCS Publishing. 3936150354 (book) ; 3936150362 (CD). pp. 117-122.

Item Type: Conference Proceedings
Abstract: In 1965 Melzack and Wall proposed the influential gate control theory of pain. This theory postulates that the substantia gelatinosa, located within the spinal cord, acts as a gate control mechanism which can influence the flow of information to the brain and thus impact on the pain experience. Subsequent research has, in general, supported this theory. The theory presented is very explicit and the fact that pain is a poorly understood phenomenon suggests it is an ideal candidate for modelling. Despite this, the utilisation of such techniques has been very limited. This paper successfully replicates the mathematical model presented by Britton and Skevington, and expands on their work to make the model more biologically plausible and provide a basis for further work with this model.
Uncontrolled Keywords: Acute pain, mathematical modelling, gate control theory, interneurons, T cells
Subjects: R Medicine > RB Pathology > RB127 Manifestations of disease > RB127.H355 Pain. Measurement
Creators: Prince, Karen, Campbell, Jackie, Picton, Philip and Turner, Scott J
Editors: Horton, Graham
Publisher: SCS Publishing
Northamptonshire and East Midlands: Health
Faculties, Divisions and Institutes: University Faculties, Divisions and Research Centres - OLD > School of Applied Sciences (to 2009)
University Faculties, Divisions and Research Centres - OLD > Faculty of Health & Society
Date: 13 June 2004
Date Type: Publication
Page Range: pp. 117-122
Title of Book: Proceedings 18th European Simulation Multiconference
Event Title: 18th European Simulation Multiconference (ESM2004): Networked Simulations and Simulated Networks
Event Dates: 13-16 June 2004
Place of Publication: Erlangen, Germany
Event Location: Magdeburg, Germany
Event Type: Conference
Number of Pages: 443
Language: English
ISBN: 3936150354 (book) ; 3936150362 (CD)
Status: Published / Disseminated
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