Prince, K., Campbell, J., Picton, P. and Turner, S. J. (2004) A computational model of acute pain. In: Horton, G. (ed.) Proceedings 18th European Simulation Multiconference. Erlangen, Germany: SCS Publishing. 3936150354 (book) ; 3936150362 (CD). pp. 117-122.
| Item Type: | Conference Proceedings |
|---|---|
| Abstract: | In 1965 Melzack and Wall proposed the influential gate control theory of pain. This theory postulates that the substantia gelatinosa, located within the spinal cord, acts as a gate control mechanism which can influence the flow of information to the brain and thus impact on the pain experience. Subsequent research has, in general, supported this theory. The theory presented is very explicit and the fact that pain is a poorly understood phenomenon suggests it is an ideal candidate for modelling. Despite this, the utilisation of such techniques has been very limited. This paper successfully replicates the mathematical model presented by Britton and Skevington, and expands on their work to make the model more biologically plausible and provide a basis for further work with this model. |
| Uncontrolled Keywords: | Acute pain, mathematical modelling, gate control theory, interneurons, T cells |
| Subjects: | R Medicine > RB Pathology > RB127 Manifestations of disease > RB127.H355 Pain. Measurement |
| Creators: | Prince, Karen, Campbell, Jackie, Picton, Philip and Turner, Scott J |
| Editors: | Horton, Graham |
| Publisher: | SCS Publishing |
| Northamptonshire and East Midlands: | Health |
| Faculties, Divisions and Institutes: |
University Faculties, Divisions and Research Centres - OLD > School of Applied Sciences (to 2009) University Faculties, Divisions and Research Centres - OLD > Faculty of Health & Society |
| Date: | 13 June 2004 |
| Date Type: | Publication |
| Page Range: | pp. 117-122 |
| Title of Book: | Proceedings 18th European Simulation Multiconference |
| Event Title: | 18th European Simulation Multiconference (ESM2004): Networked Simulations and Simulated Networks |
| Event Dates: | 13-16 June 2004 |
| Place of Publication: | Erlangen, Germany |
| Event Location: | Magdeburg, Germany |
| Event Type: | Conference |
| Number of Pages: | 443 |
| Language: | English |
| ISBN: | 3936150354 (book) ; 3936150362 (CD) |
| Status: | Published / Disseminated |
| Related URLs: | |
| URI: | http://nectar.northampton.ac.uk/id/eprint/6008 |
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