Northampton Electronic Collection of Theses and Research

A computational model simulating how pain modulation can occur through transcutaneous electrical nerve stimulation (TENS)

Prince, K., Campbell, J., Picton, P. and Turner, S. J. (2005) A computational model simulating how pain modulation can occur through transcutaneous electrical nerve stimulation (TENS). In: Petratos, P. and Michalopoulos, D. (eds.) Petratos, Panagiotis and Michalopoulos, Demetrios Computer Science and Information Systems: Selected Papers from the 1st International Conference on Computer Science and Information Systems on June 16-18, 2005. Athens, Greece: Athens Institute for Education and Research (ATINER). 9608867231. pp. 15-32.

Item Type: Conference Proceedings
Abstract: In 1965 Melzack and Wall proposed the influential gate control theory of pain. This theory postulates that the substantia gelatinosa, located within the spinal cord, acts like a gating mechanism, which modulates the flow of information through the spinal cord to the brain and thus impacts on the pain experience. Subsequent research has, in general, supported this theory. The explicitness of the theory and its well-defined architecture was translated into a mathematical model by Britton and Skevington in 1996. However, the use of such modelling has been very limited in the field of pain. he fact that pain is still relatively a poorly understood phenomenon despite the abundance of literature that is available and because of the difficulty in obtaining some experimental data, suggest that it is an ideal candidate for mathematical modelling. This paper successfully replicates the mathematical model as presented by Britton and Skevington. It uses this as a platform to develop the model further to test some of the assumptions made in its original development and, more importantly, to produce a more biologically plausible model that can be used for further applications.
Subjects: R Medicine > RB Pathology > RB127 Manifestations of disease > RB127.H355 Pain. Measurement
R Medicine > RM Therapeutics. Pharmacology > RM871 Electrotherapeutics
Creators: Prince, Karen, Campbell, Jackie, Picton, Philip and Turner, Scott J
Editors: Petratos, Panagiotis and Michalopoulos, Demetrios
Publisher: Athens Institute for Education and Research (ATINER)
Northamptonshire and East Midlands: Health
Faculties, Divisions and Institutes: University Faculties, Divisions and Research Centres - OLD > School of Applied Sciences (to 2009)
University Faculties, Divisions and Research Centres - OLD > Faculty of Health & Society
Date: 2005
Date Type: Publication
Page Range: pp. 15-32
Title of Book: Computer Science and Information Systems: Selected Papers from the 1st International Conference on Computer Science and Information Systems on June 16-18, 2005
Event Title: International Conference on Computer Science and Information Systems
Event Dates: 16-18 June 2005
Place of Publication: Athens, Greece
Event Location: Athens, Greece
Event Type: Conference
Number of Pages: 440
Language: English
ISBN: 9608867231
Status: Published / Disseminated
URI: http://nectar.northampton.ac.uk/id/eprint/6006

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