Machado, L., Jarrett, R., Morgan, S., Murray, P., Hunter, B., Hamilton, E., Crocker, J., Thomas, W., Steven, N., Ismail, T., Chapman, A., Adams, D. H. and Lee, S. P. (2009) Expression and function of T cell homing molecules in Hodkins's lymphoma. Cancer Immunology, Immunotherapy. 58(1), pp. 85-94. 0340-7004.
- Information
Information
Abstract:
Circulating T lymphocytes enter a tissue if they
express appropriate chemokine receptors and adhesion
molecules to engage ligands presented at this site. To aid
rational development of T cell-based therapies for Hodgkin’s
lymphoma (HL), we have assessed the expression and
function of homing receptors on tumour-inWltrating T cells
in HL and compared them with T cells from unaVected
lymph nodes and colorectal cancer tissue. Chemokine
receptors CXCR3, CXCR4 and CCR7 were expressed on a
large proportion of T cells within HL tissue and mediated
chemotaxis to puriWed chemokine. The corresponding
ligands (CXCL10, CXCL12, CCL21) were expressed on
the malignant cells and/or vascular endothelium. Adhesion
molecules including CD62L were widely expressed on
HL-derived T cells and their corresponding ligands were
detected on vessels within the tumour. This homing phenotype
was distinct from T cells isolated from colorectal cancer,
but matched closely the phenotype of T cells from
unaVected lymph nodes. Thus, T cell recruitment to HL
resembles entry of naïve/central memory T cells into normal
lymph nodes. This has important implications for current
approaches to treat HL using T cells activated and
expanded in vitro that lack CCR7 and CD62L expression
Uncontrolled Keywords:
Chemokines, Hodgkin’s lymphoma, tumour immunity, T cell homing
Subjects:
Creators:
Machado, L., Jarrett, R., Morgan, S., Murray, P., Hunter, B., Hamilton, E., Crocker, J., Thomas, W., Steven, N., Ismail, T., Chapman, A., Adams, D. H. and Lee, S. P.
Publisher:
Springer
Faculties, Divisions and Institutes:
University Faculties, Divisions and Research Centres - OLD > Faculty of Health & Society > Sports, Exercise & Life Sciences
University Faculties, Divisions and Research Centres - OLD > Research Centre > Institute of Health and Wellbeing > Ageing Research Centre
Faculties > Faculty of Health & Society > Sports, Exercise & Life Sciences
Research Centres > Centre for Health Sciences and Services
Research Centres > Centre for Physical Activity and Life Sciences
University Faculties, Divisions and Research Centres - OLD > Research Centre > Institute of Health and Wellbeing > Ageing Research Centre
Faculties > Faculty of Health & Society > Sports, Exercise & Life Sciences
Research Centres > Centre for Health Sciences and Services
Research Centres > Centre for Physical Activity and Life Sciences
Date:
January 2009
Date Type:
Publication
Page Range:
pp. 85-94
Journal or Publication Title:
Cancer Immunology, Immunotherapy
Volume:
58
Number:
1
Language:
English
ISSN:
0340-7004
Status:
Published / Disseminated
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