A significant step in the development of biocomputing has been made with the fabrication of the first electrically wired enzyme system assembled on an electrode surface capable of performing various logic operations depending on the applied potential, permitting electrical interfacing between biomolecular computing systems and ‘normal’ electronics (M Pita, E Katz; J. Am. Chem. Soc., 2008, 130, 36) (Scheme 1)