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An Updated Classification System and Review of the Lipooligosaccharide Biosynthesis Gene Locus in Campylobacter jejuni

Machado, L., Woodacre, A., Hameed, A. and Marsden, G. L. (2020) An Updated Classification System and Review of the Lipooligosaccharide Biosynthesis Gene Locus in Campylobacter jejuni. Frontiers in Microbiology. 11(677), pp. 1-11. 1664-302X.

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Machado_etal_FM_2020_An_Updated_Classification_System_and_Review_of_the_Lipooligosaccharide_Biosynthesis_Gene_Locus_in_Campylobacter_jejuni
Machado_etal_FM_2020_An_Updated_Classification_System_and_Review_of_the_Lipooligosaccharide_Biosynthesis_Gene_Locus_in_Campylobacter_jejuni.pdf - Accepted Version
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Abstract:
Lipooligosaccharide (LOS) is an integral component of the Campylobacter cell membrane with a structure of core oligosaccharides forming inner and outer core regions and a lipid A moiety. The gene content of the LOS core biosynthesis cluster exhibits extensive sequence variation, which leads to the production of variable cell surface LOS structures in Campylobacter. Some LOS outer core molecules in Campylobacter jejuni are molecular mimics of host structures (such as neuronal gangliosides) and are thought to trigger neuronal disorders (particularly Guillain-Barré syndrome and Miller Fisher syndrome) in humans. The extensive genetic variation in the LOS biosynthesis gene cluster, a majority of which occurs in the LOS outer core biosynthesis gene content present between lgtF and waaV, has led to the development of a classification system with 23 classes (A-W) and four groups (1-4) for the C. jejuni LOS region. This review presents an updated and simplified classification system for LOS typing alongside an overview of the frequency of C. jejuni LOS biosynthesis genotypes and structures in various C. jejuni populations.
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2725
Creators:
Machado, L., Woodacre, A., Hameed, A. and Marsden, G. L.
Faculties, Divisions and Institutes:
?? ASSCI ??
Research Centres > Centre for Physical Activity and Life Sciences
Date:
19 May 2020
Date Type:
Publication
Page Range:
pp. 1-11
Journal or Publication Title:
Frontiers in Microbiology
Volume:
11
Number:
677
Number of Pages:
11
Language:
English
DOI:
10.3389/fmicb.2020.00677
ISSN:
1664-302X
Status:
Published / Disseminated
Refereed:
Yes
Related URLs:
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