Northampton Electronic Collection of Theses and Research

Properdin is a modulator of tumour immunity in a syngeneic mouse melanoma model

Machado, L., Al-Rayahi, I. A. M. and Stover, C. (2021) Properdin is a modulator of tumour immunity in a syngeneic mouse melanoma model. Medicina. 57(2) 1010-660X.

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2021_Machado_Lee_Abdulsatar_Mezher_Al-Rayahi_Izzat_Stover_Cordula_MDPI_Properdin_is_a_modulator_of tumour_immunity_in_a_syngeneic_mouse_melanoma_model
2021_Machado_Lee_Abdulsatar_Mezher_Al_Rayahi_Izzat_Stover_Cordula_MDPI_Properdin_is_a_modulator_of_tumour_immunity_in_a_syngeneic_mouse_melanoma_model.pdf - Published Version
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Information
Abstract:
Background and Objectives: Tumours are often low immunogenic. The role of complement, an innate immune defence system, in tumour control has begun to be elucidated, but findings are conflicting. A role for properdin, an amplifier of complement activation, in tumour control has recently been implicated. Materials and Methods: Properdin-deficient and congenic wildtype mice were injected subcutaneously with B16F10 melanoma cells. Tumour mass and chemokine profile were assessed. The frequencies of CD45+CD11b+ Gr-1+ cells were determined from tumours and spleens, and CD206+ F4/80+ cells were evaluated in spleens. Sera were analysed for C5a, sC5b-9, and CCL2. Results: Whilst there was no difference in tumour growth at study endpoint, properdin-deficient mice had significantly fewer myeloid-derived suppressor cells (MDSCs) in their tumours and spleens. Splenic M2 type macrophages and serum levels of C5a, sC5b-9, and CCL2 were decreased in properdin-deficient compared to wildtype mice. Conclusions: The presence of intact complement amplification sustains an environment that lessens potential anti-tumour responses.
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1300/1306
Creators:
Machado, L., Al-Rayahi, I. A. M. and Stover, C.
Faculties, Divisions and Institutes:
?? ASSCI ??
Research Centres > Centre for Physical Activity and Life Sciences
Date:
21 January 2021
Date Type:
Publication
Journal or Publication Title:
Medicina
Volume:
57
Number:
2
Number of Pages:
8
Language:
English
DOI:
10.3390/medicina57020085
ISSN:
1010-660X
Status:
Published / Disseminated
Refereed:
Yes
Related URLs:
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