Machado, L., Al-Rayahi, I. A. M. and Stover, C. (2021) Properdin is a modulator of tumour immunity in a syngeneic mouse melanoma model. Medicina. 57(2) 1010-660X.
| Item Type: | Article |
|---|---|
| Abstract: | Background and Objectives: Tumours are often low immunogenic. The role of complement, an innate immune defence system, in tumour control has begun to be elucidated, but findings are conflicting. A role for properdin, an amplifier of complement activation, in tumour control has recently been implicated. Materials and Methods: Properdin-deficient and congenic wildtype mice were injected subcutaneously with B16F10 melanoma cells. Tumour mass and chemokine profile were assessed. The frequencies of CD45+CD11b+ Gr-1+ cells were determined from tumours and spleens, and CD206+ F4/80+ cells were evaluated in spleens. Sera were analysed for C5a, sC5b-9, and CCL2. Results: Whilst there was no difference in tumour growth at study endpoint, properdin-deficient mice had significantly fewer myeloid-derived suppressor cells (MDSCs) in their tumours and spleens. Splenic M2 type macrophages and serum levels of C5a, sC5b-9, and CCL2 were decreased in properdin-deficient compared to wildtype mice. Conclusions: The presence of intact complement amplification sustains an environment that lessens potential anti-tumour responses. |
| Uncontrolled Keywords: | /dk/atira/pure/subjectarea/asjc/1300/1306 |
| Creators: | Machado, Lee, Al-Rayahi, Izzat Abdulsatar Mezher and Stover, Cordula |
| Faculties, Divisions and Institutes: |
?? ASSCI ?? Research Centres > Centre for Physical Activity and Life Sciences |
| Date: | 21 January 2021 |
| Date Type: | Publication |
| Journal or Publication Title: | Medicina |
| Volume: | 57 |
| Number: | 2 |
| Number of Pages: | 8 |
| Language: | English |
| DOI: | https://doi.org/10.3390/medicina57020085 |
| ISSN: | 1010-660X |
| Status: | Published / Disseminated |
| Refereed: | Yes |
| Related URLs: | |
| URI: | http://nectar.northampton.ac.uk/id/eprint/13989 |
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