Northampton Electronic Collection of Theses and Research

Gelatin porous scaffolds fabricated using a modified gas foaming technique: Characterisation and cytotoxicity assessment

Poursamar, S. A., Hatami, J., Lehner, A. N., da Silva, C., Ferreira, F. and Antunes, A. P. M. (2015) Gelatin porous scaffolds fabricated using a modified gas foaming technique: Characterisation and cytotoxicity assessment. Materials Science and Engineering: C. 48, pp. 63-70. 0928-4931.

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13877:32252
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Poursamar_etal_ELS_2014_Gelatin_porous_scaffolds_fabricated_using_a_modified_gas_foaming_technique_Characterisation_and_cytotoxicity_assessment
Poursamar_etal_ELS_2014_Gelatin_porous_scaffolds_fabricated_using_a_modified_gas_foaming_technique_Characterisation_and_cytotoxicity_assessment.pdf - Accepted Version
Information
Abstract:
The current study presents an effective and simple strategy to obtain stable porous scaffolds from gelatin via a gas foaming method. The technique exploits the intrinsic foaming ability of gelatin in the presence of CO2 to obtain a porous structure stabilised with glutaraldehyde. The produced scaffolds were characterised using physical and mechanical characterisation methods. The results showed that gas foaming may allow the tailoring of the 3-dimensional structure of the scaffolds with an interconnected porous structure. To assess the effectiveness of the preparation method in mitigating the potential cytotoxicity risk of using glutaraldehyde as a crosslinker, direct and in-direct cytotoxicity assays were performed at different concentrations of glutaraldehyde. The results indicate the potential of the gas foaming method, in the preparation of viable tissue engineering scaffolds.
Uncontrolled Keywords:
Gelatin, Gas foaming, Crosslinking, Tensile strength, Denaturation temperature
Creators:
Poursamar, S. A., Hatami, J., Lehner, A. N., da Silva, C., Ferreira, F. and Antunes, A. P. M.
Faculties, Divisions and Institutes:
Research Institutes > Institute for Creative Leather Technologies
Research Centres > Centre for Health Sciences and Services
Research Centres > Centre for Physical Activity and Life Sciences
Date:
1 March 2015
Date Type:
Publication
Page Range:
pp. 63-70
Journal or Publication Title:
Materials Science and Engineering: C
Volume:
48
Number of Pages:
8
Language:
English
DOI:
10.1016/j.msec.2014.10.074
ISSN:
0928-4931
Status:
Published / Disseminated
Refereed:
Yes
Related URLs:
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