Griffiths, C., Da Silva, K., de Vail, R. and O'Neill-Kerr, A. (2019) Repetitive Transcranial Magnetic Stimulation (rTMS) in Treatment Resistant Depression : Retrospective Data Analysis from Clinical Practice. Open Journal of Depression. 8(1), pp. 16-28. 2169-9674.
| Item Type: | Article |
|---|---|
| Abstract: | Objective: The aim of this paper is to present the service data results from a clinical repetitive Transcranial Magnetic Stimulation (rTMS) service treating treatment resistant depression (TRD). Methods The study was a retrospective investigation of routinely collected data on patients receiving rTMS between 2015 and 2018. Measures used were the clinician-rated Clinical Global Impression (CGI) and Hamilton Depression Rating Scale (HAM-D), and patient rated Physical Health Questionnaire (PHQ-9) and Generalised Anxiety Disorder 7 (GAD-7). The outcome data of 144 patients with TRD was analysed. The sample included patients with co-morbid psychiatric diagnosis. Results Response and remission rates respectively were 34.6% and 20.6% for the HAM-D; 10% and 28.6% for the PHQ-9; 31% and 31.8% for the CGI; and 24.6% and 28.8% for GAD-7. Effect sizes were mostly medium (0.48, 0.27, 0.51, 0.43 respectively). GAD-7 reliable change improvement was 56.1% and PHQ-9 reliable change improvement was 40%. There was a medium positive correlation between anxiety (GAD-7) and depression recovery (HAM-D), r = .31, n = 46, p = .039, with lower pre-treatment anxiety associated with lower post-treatment HAM-D scores. Conclusions TRD patients with low pre-treatment anxiety levels respond to treatment better than those with high pre-treatment anxiety. The results show that a clinical rTMS service can have a significant impact on symptoms of depression and anxiety in TRD. The findings support wider availability of rTMS as a treatment option for people with TRD. |
| Uncontrolled Keywords: | Repetitive Transcranial Magnetic Stimulation (rTMS), treatment resistant depression, service delivery, anxiety |
| Creators: | Griffiths, Chris, Da Silva, Ksenija, de Vail, Robert and O'Neill-Kerr, Alex |
| Faculties, Divisions and Institutes: | Faculties > Faculty of Health & Society > Psychology |
| Date: | 17 January 2019 |
| Date Type: | Publication |
| Page Range: | pp. 16-28 |
| Journal or Publication Title: | Open Journal of Depression |
| Volume: | 8 |
| Number: | 1 |
| Number of Pages: | 13 |
| Language: | English |
| DOI: | https://doi.org/10.4236/ojd.2019.81003 |
| ISSN: | 2169-9674 |
| Status: | Published / Disseminated |
| Refereed: | Yes |
| Related URLs: | |
| URI: | http://nectar.northampton.ac.uk/id/eprint/12474 |
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