Poursamar, S. A., Hatami, J., Lehner, A. N., da Silva, C., Ferreira, F. and Antunes, A. P. M. (2015) Gelatin porous scaffolds fabricated using a modified gas foaming technique: Characterisation and cytotoxicity assessment. Materials Science and Engineering: C. 48 0928-4931.
| Item Type: | Article |
|---|---|
| Abstract: | The current study presents an effective and simple strategy to obtain stable porous scaffolds from gelatin via a gas foaming method. The technique exploits the intrinsic foaming ability of gelatin in the presence of CO2 to obtain a porous structure stabilised with glutaraldehyde. The produced scaffolds were characterised using physical and mechanical characterisation methods. The results showed that gas foaming may allow the tailoring of the 3-dimensional structure of the scaffolds with an interconnected porous structure. To assess the effectiveness of the preparation method in mitigating the potential cytotoxicity risk of using glutaraldehyde as a crosslinker, direct and in-direct cytotoxicity assays were performed at different concentrations of glutaraldehyde. The results indicate the potential of the gas foaming method, in the preparation of viable tissue engineering scaffolds. |
| Uncontrolled Keywords: | crosslinking, denaturation temperature, gas foaming, gelatin, tensile strength |
| Creators: | Poursamar, Seyed Ali, Hatami, Javad, Lehner, Alexander N, da Silva, Claudio, Ferreira, Frederico and Antunes, A Paula M |
| Faculties, Divisions and Institutes: |
Research Institutes > Institute for Creative Leather Technologies Research Centres > Centre for Health Sciences and Services Research Centres > Centre for Physical Activity and Life Sciences |
| Date: | 1 March 2015 |
| Date Type: | Publication |
| Journal or Publication Title: | Materials Science and Engineering: C |
| Volume: | 48 |
| Language: | English |
| DOI: | https://doi.org/10.1016/j.msec.2014.10.074 |
| ISSN: | 0928-4931 |
| Status: | Published / Disseminated |
| Refereed: | Yes |
| URI: | http://nectar.northampton.ac.uk/id/eprint/11075 |
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