Potential application of gelatin scaffolds prepared through in situ gas foaming in skin tissue engineering

Poursamar, S. A., Hatami, J., Lehner, A. N., da Silva, C. L., Ferreira, F. C. and Antunes, A. P. M. (2016) Potential application of gelatin scaffolds prepared through in situ gas foaming in skin tissue engineering. International Journal of Polymeric Materials and Polymeric Biomaterials. 65(6), pp. 315-322. 0091-4037.

Poursamar_etal_TFO_2016_Potential_application_of_gelatin_scaffolds_prepared_through_in_situ_gas_foaming_in ... (1MB)

Item Type:	Article
Abstract:	Gelatin’s excellent foaming ability allows the application of in situ gas foaming as a preparation technique for porous scaffold development. Here, a new iterative experimental design for in situ gas foaming method is reported. The prepared scaffolds were studied for applying the findings to the future skin tissue engineering scaffolds. The thermal stability, mechanical properties, and pore structure of the scaffolds are reported and their degradation resistance by using collagenase enzyme and their cytotoxicity by using fibroblasts were studied. The results of this study demonstrated that gas foaming method can be modified to produce an interconnected porous structure with enhanced mechanical properties.
Uncontrolled Keywords:	Gelatin, cytotoxicity, gas foaming, tensile strength, wound dressing
Creators:	Poursamar, Seyed Ali, Hatami, Javad, Lehner, Alexander N, da Silva, Claudia L, Ferreira, Frederico Castelo and Antunes, A Paula M
Faculties, Divisions and Institutes:	Research Institutes > Institute for Creative Leather Technologies Research Centres > Centre for Health Sciences and Services Research Centres > Centre for Physical Activity and Life Sciences
Date:	8 January 2016
Date Type:	Publication
Page Range:	pp. 315-322
Journal or Publication Title:	International Journal of Polymeric Materials and Polymeric Biomaterials
Volume:	65
Number:	6
Number of Pages:	8
Language:	English
DOI:	https://doi.org/10.1080/00914037.2015.1119688
ISSN:	0091-4037
Status:	Published / Disseminated
Refereed:	Yes
Related URLs:	https://pure.northampton.ac.uk/en/public...
URI:	http://nectar.northampton.ac.uk/id/eprint/11062

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