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Mitochondrial respiration is decreased in rat kidney following fetal exposure to a maternal low-protein diet

Engeham, S., Mdaki, K., Jewell, K., Austin, R., Lehner, A. N. and Langley-Evans, S. C. (2012) Mitochondrial respiration is decreased in rat kidney following fetal exposure to a maternal low-protein diet. Journal of Nutrition and Metabolism. 2012 2090-0724.

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Mitochondrial Respiration is decreased in Rat Kidney Following Fetal Exposure to a Maternal Low-Protein Diet
Mitochondrial_Respiration_is_decreased_in_Rat_Kidney_Following_Fetal_Exposure_to_a_Maternal_Low_Protein_Diet.pdf - Published Version
Information
Abstract:
Maternal protein restriction in rat pregnancy is associated with impaired renal development and age-related loss of renal function in the resulting offspring. Pregnant rats were fed either control or low-protein (LP) diets, and kidneys from their male offspring were collected at 4, 13, or 16 weeks of age. Mitochondrial state 3 and state 4 respiratory rates were decreased by a third in the LP exposed adults. The reduction in mitochondrial function was not explained by complex IV deficiency or altered expression of the complex I subunits that are typically associated with mitochondrial dysfunction. Similarly, there was no evidence that LP-exposure resulted in greater oxidative damage to the kidney, differential expression of ATP synthetase β-subunit, and ATP-ADP translocase 1. mRNA expression of uncoupling protein 2 was increased in adult rats exposed to LP in utero, but there was no evidence of differential expression at the protein level. Exposure to maternal undernutrition is associated with a decrease in mitochondrial respiration in kidneys of adult rats. In the absence of gross disturbances in respiratory chain protein expression, programming of coupling efficiency may explain the long-term impact of the maternal diet.
Uncontrolled Keywords:
/dk/atira/pure/sustainabledevelopmentgoals/zero_hunger
Creators:
Engeham, S., Mdaki, K., Jewell, K., Austin, R., Lehner, A. N. and Langley-Evans, S. C.
Faculties, Divisions and Institutes:
Faculties > Faculty of Health & Society > Sports, Exercise & Life Sciences
Research Centres > Centre for Health Sciences and Services
Research Centres > Centre for Physical Activity and Life Sciences
Date:
27 March 2012
Date Type:
Publication
Journal or Publication Title:
Journal of Nutrition and Metabolism
Volume:
2012
Language:
English
DOI:
10.1155/2012/989037
ISSN:
2090-0724
Status:
Published / Disseminated
Refereed:
Yes
Related URLs:
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